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Publications
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1
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Akins DR, Caimano MJ, Yang X, Cerna F, Norgard MV, Radolf
JD. 1999. Molecular and evolutionary analysis of Borrelia burgdorferi 297 circular plasmid-encoded lipoproteins
with OspE- and OspF-like leader peptides. Infect Immun. 67(3):1526-32.
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2
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Yang X, Taissia P, Hagman
K, Wikel S, Schoeler G,
Caimano M, Radolf J, Norgard MV. 1999. Identification, characterization, and
expression of three new members of the Borrelia
burgdorferi Mlp (2.9) lipoproteins gene family. Infect. Immun. 67(11):6008-18.
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3
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Caimano M, Yang X,
Popova T, Clawson M, Akins D, Norgard MV, Radolf J.
2000. Molecular and evolutionary characterization of the cp32/cp18 family of supercoil plasmid in Borrelia
burgdorferi 297. Infect. Immun. 68(3):1574-86.
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4
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Yang, X, Goldberg MS, Popova T, Schoeler
G, Wikel S, Hagman K,
Norgard MV. 2000. Interdependence of environmental factors influencing
reciprocal patterns of gene expression in virulent Borrelia burgdorferi
297. Mol.
Microbiol. 37:1470-9.
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5
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Hagman K, Yang X, Wikel
S, Schoeler G, Caimano M, Radolf J, Norgard MV.
2000. Decorn-binding protein A (DbpA)
of Borrelia burgdorferi is not
protective when immunized mice are challenged via tick infestation and
correlates with the lack of DbpA expression by B.
burgdorferi in ticks. Infect. Immun. 68(8):4759-64.
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6
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Yang, X, Taissia P,
Goldberg MS, Norgard MV. 2001. Influence of cultivation
media on genetic regulatory patterns in Borrelia
burgdorferi. Infect. Immun. 69(6):4159-63.
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7
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Hubner A, Yang X, Nolen D, Popova
T, Cabello FC, Norgard MV. 2001. Expression of Borrelia burgdorferi OspC and DbpA is
controlled by a novel RpoN-RpoS pathway. Proc. Natl. Acad.Sci.
USA. 98:12724-9.
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8
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Yang X, Hubner A,
Popova T, Hagman KE, Norgard MV. 2003. Regulation of
expression of the Mlp paralogous in Borrelia
burgdorferi. Infect. Immun. 71:5012-20.
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9
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Yang X, Alani SM,
Norgard MV. 2003. The response regulator
Rrp2 is essential for the expression of major membrane lipoproteins in Borrelia burgdorferi. Proc. Natl. Acad. Sci. USA.
100(19):11001-6.
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10
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Harrod AC, Yang X*, Junker M, Reitzer L. 2004. Evidence that
a-helix five of the amino terminal domain of the response regulator nitrogen
regulator I of Escherichia coli interacts with the central domain. J. Biol. Chem. 279(4):
2350-9. (*co-first author)
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11
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Pal, U, Yang X*,
Chen M, Bockenstedt LK, Anderson JF, Flavell RA, Norgard MV, Fikrig E. 2004. OspC
facilitates Borrelia burgdorferi
colonization of Ixodes scapularis salivary glands. J. Clin.
Invest. 113: 220-30. (*co-first author)
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12
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Yang XF, Ji Y,
Schneider BL, Reitzer L. 2004. Phosphorylation-independent
dimer-dimer interactions by the enhancer-binding activator NtrC of Escherichia coli: a third function for the carboxy-terminal
domain. J.
Biol. Chem. 279(35):36708-14.
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13
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Blevins JS, Revel AT, Caimano MJ, Yang XF, Richardson JA, Hagman K,
Norgard MV. 2004. The luxS
gene is not required for Borrelia.
Burgdorferi tick colonization, transmission to a mammalian host, or
induction of disease. Infect. Immun. 27(8):4864-7.
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14
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Yang XF, Pal U, Alani
SM, Fikrig E, Norgard MV. 2004. Essential role for OspA/B in
the life cycle of the Lyme disease spirochete. J.
Exp. Med. 199(5):641-8.
(Cover Image) (Commentary
1) (Commentary 2)
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15
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Pal U, Li X, Wang T, Montgomery RR, deSilva AM, Bao F, Ramamoorthi N, Yang, XF, Kantor FS, Telford S, Pypaert M, Anderson JF, Fikrig E. 2004.
TROSPA, an Ixodes scapularis
receptor for Borrelia burgdorferi. Cell. 119(12):457-68.
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16
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Yang XF, Lybecker MC, Pal U, Alani SM, Blevins JS, Revel AT, Samuels DS,
Norgard MV. 2005. Analysis of the ospC
regulatory element controlled by the RpoN-RpoS regulatory pathway in Borrelia burgdorferi. J. Bacteriol. 187(14):4822-9.
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17
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Ramamoorthi N, Narasimhan
S, Pal U, Bao F, Yang XF, Fish D, Anguita J, Norgard MV,
Kantor FS, Anderson JF, Koski RA, Fikrig E. 2005. The Lyme disease agent exploits a tick
protein to infect the mammalian host. Nature. 436:573-7. (see
Commentary)
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18
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Deka RK, Brautigam CA, Yang XF, Blevins JS, Machius M, Tomchick DR,
Norgard, MV. 2006. The PnrA (Tp0319; TmpC) lipoprotein represents a new family of bacterial
purine nucleoside receptor encoded within an ATP-binding cassette (ABC)-like
operon in Treponema pallidum. J.
Biol. Chem. 281(12):8072-81.
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19
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Smith AlH, Blevins JS, Gulnaz N. Bachlani, GN, Yang XF, Norgard, MN. 2006. Evidence
that RpoS (σS) in Borrelia
burgdorferi is controlled directly by RpoN (σ54/σN). J. Bacteriol. 189(5):2139-44.
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20
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He M, Boardman BK, Yan D, Yang XF. 2007.
Regulation of expression of the fibronectin-binding protein BBK32 in Borrelia
burgdorferi. J Bacteriol.
189(22):8377-80
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21
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Boardman BK, He M, Ouyang Z, Xu H, Pang X, Yang XF.
2008. Essential role of the response regulator Rrp2 in the infectious cycle
of Borrelia burgdorferi. Infect. Immun. 76(9):
3844–3853
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22
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Yang XF, Goldberg MS, He M, Xu H,
Blevins J, Norgard, MV. 2008. Differential Expression of a Putative CarD-like Transcriptional Regulator, LtpA,
in Borrelia burgdorferi. Infect. Immun. 76(10):4439–44
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23
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He M, Oman T,
Xu H, Blevins, JS, Norgard MV, Yang XF. 2008. Abrogation of ospAB constitutively activates the Rrp2-RpoN-RpoS
pathway (SigmaN-SigmaS cascade) in Borrelia burgdorferi.
Mol. Microbiol.
70(6):1453-64
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24
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Ouyang Z, He
M, Oman T, Yang XF, Norgard MV. 2009. A manganese transporter, BB0219
(BmtA), is required for virulence by the Lyme
disease spirochete, Borrelia burgdorferi. Proc Natl Acad
Sci U S A. 106(9):3449-54
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25
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Blevins JS, Xu
H, He M, Norgard MV, Reitzer L, Yang XF. 2009. Rrp2, a s54-dependent
transcriptional activator of Borrelia burgdorferi, activates rpoS
in an enhancer-independent manner. J
Bacteriol. 191(8):2902-5.
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26
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Xu H, He M,
Pang X, Xu ZC, Piesman J, Yang XF. 2010.
Characterization of the highly regulated antigen BBA05 in the enzootic cycle
of Borrelia burgdorferi. Infect. Immun. 78(1):100-7.
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27
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Xu H, He, M,
He, JJ, Yang XF. 2010. The
role of the surface lipoprotein BBA07 in the enzootic cycle of Borrelia
burgdorferi. Infect.
Immun. 78:2910-18.
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28
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Zou,W, Wang Z, LiuY,
Fan Y, Zhou BY, Yang XF, He JJ. 2010. Involvement of p300 in
constitutive and HIV-1 Tat-activated expression of glial
fibrillary acidic protein in astrocytes.
GLIA. 58(13):1640-8.
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29
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Xu H, Caimano
M, Lin T, He M, Radolf J, Norris S, Gheradini F,
Wolfe A, Yang XF. 2010. Role of
acetyl-phosphate in activation of the Rrp2-RpoN-RpoS pathway in Borrelia
burgdorferi. PLOS Pathogens. 6(9): e1001104. doi:10.
1371/journal.ppat. 1001104
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30
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Xue F, Dong H,
Wu J, Wu Z, Zhao J, Hu W,Bu L, Sun A, Li L, Troxell
B, Yang XF, Yan J. 2010. Transcriptional Responses of Leptospira
interrogans to Host Innate Immunity: Significant Changes in Metabolism,
Oxygen Tolerance, and Outer Membrane.
PLoS Negl
Trop Dis 4(10):
e857. doi:10.1371/journal.pntd.0000857
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31
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He M, Ouyang
Z, Troxell B, Xu H, Moh A, Piesman J, Norgard MV, Gomelsky M, Yang XF.
2011. Cyclic di-GMP Is Essential for the Survival
of the Lyme Disease Spirochete in Ticks. PLoS Pathog 7(6): e1002133. doi: 10.1371/journal.ppat.1002133
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