http://www.iupui.edu/~solctr/research/ Through the Solution Center, IUPUI will share its expertise in research, from unraveling the mysteries of Genomics to economic and community development. The Solution Center identifies and strengthens campus connections that allow industry representatives and businesses to access resesearch, resources, and technology available at IUPUI. http://www.iupui.edu/~solctr/research/details.php?id=343 The ACT Center of Indiana is a collaboration of the Department of Psychology at IUPUI and the Adult and Child Center of Indianapolis. It is our mission to integrate research and practice to promote implementation of and continued commitment to high-quality, recovery-focused, evidence-based practices for adults with severe mental illness. Through training, research, and technical assistance, we strive to assist Assertive Community Treatment (ACT), Integrated Dual Disorders Treatment (IDDT), and Illness Management and Recovery (IMR) programs across the state in providing services with high fidelity to the model and strong recovery outcomes for consumers. Our approach is to combine training and implementation with ongoing program evaluation and research. http://www.iupui.edu/~solctr/research/details.php?id=209 The mission of Advanced Engineering and Manufacturing Laboratory (AEML) is to provide technical service and support to local industry and solve problems in advanced manufacturing, design, and analysis. The Lab also provides facilities for teaching and research in the areas of CAD Computer Aided Design), CAE (Computer Aided Engineering), CAM Computer Aided Manufacturing), IPS (Interactive Product Simulation), and PDM (Product Data Management). The laboratory is equipped with integrated CAD/CAE/CAM/PDM facilities (software and hardware) which are used as the base to conduct fundamental research, promote applied research activities, attract industrial projects, and teach the next generation engineering and technology students. It creates a base to train high-tech and advanced manufacturing workforces to meet the needs of the rapid changing technology and provide service to industry. The laboratory is involved in fundamental as well as applied esearch in the areas of advanced manufacturing, intelligent machining, engineering design, analysis, simulation and Product Data Management. http://www.iupui.edu/~solctr/research/details.php?id=281 The Advanced Information Technology Core supports aspects of research in medicine, genomics, bioinformatics, and medical informatics that depend heavily on computation, data management, or novel IT solutions. The mission of the Advanced IT Core is to provide supercomputing, bioinformatics software, massive data storage, and advanced visualization services to researchers in the life sciences, especially those in the IU School of Medicine. http://www.iupui.edu/~solctr/research/details.php?id=210 The Advance Visualization Lab provides hardware and software resources, expert consulting, research support, and education and outreach opportunities for scientific visualization, virtual reality, high-end computer graphics, and visual tele-collaboration. The AVL engages in projects and partnerships with researchers, educators and artists from all IU departments and campuses. http://www.iupui.edu/~solctr/research/details.php?id=211 The Amyloid Research Group conducts research on all types of Amyloidosis. http://www.iupui.edu/~solctr/research/details.php?id=212 The Animal Stem Cell Core is dedicated to providing IU investigators technical expertise and resources in the derivation and developmental analysis of embryonic stem cells obtained from transgenic or knockout mice. http://www.iupui.edu/~solctr/research/details.php?id=213 The ACT Center of Indiana is a collaboration of the Department of Psychology at IUPUI and the Adult and Child Center of Indianapolis. In addition to the ACT initiative, the state of Indiana and the ACT Center of Indiana made a commitment in 2002 to assist in the implementation of Integrated Dual Disorders Treatment (IDDT) programs throughout the state. This commitment was a result of our being selected to participate in the larger National Implementing Evidenced Based Practices (EBP) Project. In 2003, we began helping programs implement Illness Management and Recovery (IMR) through two federally-funded grant projects. http://www.iupui.edu/~solctr/research/details.php?id=214 The Automotive Safety Program at James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, began initially in 1981 as a model car seat loan program with the mission to train educators throughout the state to establish and maintain car seat loan programs. Since that time, the Program has taken on a strong leadership role statewide as an advocacy program for all aspects of child passenger safety. Using a wide variety of creative education and public information strategies, the program has been able to reach audiences of all ages, backgrounds, and needs. Children with a variety of disabilities often have needs that prohibit the use of standard child restraint devices. The Automotive Safety Program has conducted research to evaluate devices appropriate for safely transporting children with special needs. Many of these safety- tested restraint systems are now available either commercially or through special needs safety restraint loan programs. http://www.iupui.edu/~solctr/research/details.php?id=215 The Biochemistry Biotechnology Facility (BBF)offers an automated DNA sequencing service which can be used for sequence of analysis of plasmid, PCR, and large DNA samples. This service utilizes a Perkin Elmer/Applied Biosystems 3100 Genetic Analyzer and Big Dye Terminator chemistry v3.1. We routinely provide between 700 to 1000 bases per reaction. The turn-around time for DNA sequence data is generally 24 hours from sample submission, if all sample requirements are met. Data is supplied as a hard copy electrophoretograph and text data files can be retrieved electronically from this web site by researchers at Indiana University. For questions or a more detailed discussion about this service, please contact Sequencing personnel. http://www.iupui.edu/~solctr/research/details.php?id=216 The focus of the BMRL is on the mechanical engineering aspects of dentistry; namely areas of biomechanics and biomaterials. http://www.iupui.edu/~solctr/research/details.php?id=217 The Biomedical Signal Processing Laboratory focuses on problems in cardiac electrophysiology. The local area network has 13 PCs with a full compliment of biophysical measurement capability. This includes a clinical ECG recorder, four 24-hour ambulatory ECG recorders, a high resolution ECG system, and a 128-channel cardiac mapping system. Close collaboration exists between this laboratory and the Krannert Institute of Cardiology for doing in vitro experiments and clinical studies. http://www.iupui.edu/~solctr/research/details.php?id=218 The Division of Biostatistics provides leadership in the planning, statistical design, data management, and analysis of clinical, laboratory and epidemiological studies for the School of Medicine and other schools working in the health sciences. The mission is carried out through teaching, research, and service activities related to biostatistics and epidemiology. http://www.iupui.edu/~solctr/research/details.php?id=219 The Biostatistics and Data Management Core (BDMC) of the Indiana University Cancer Center assumes statistical and data management responsibilities and associated administrative functions, education, and training. The core collaborates with investigators in the planning, design, development, and analysis of the full range of cancer research projects, including clinical trials, cancer control studies, behavioral research, and basic laboratory science. It participates in every level of research, from study planning and monitoring to data analysis and dissemination of results. The specific aims of the BDMC are to: 1) provide broad statistical and data management support to IUCC investigators; 2) conduct application-driven statistical methodological research; and 3) provide an educational resource to IUCC investigators. http://www.iupui.edu/~solctr/research/details.php?id=220 In response to the expanding frontiers in biotechnology and the biomedical sciences, the Indiana University School of Medicine has created the Biotechnology Training Program. The program, geared toward students wanting to boost their career in the sciences, offers a Graduate Certificate in Biotechnology and a Master\\\'s degree in Biotechnology -- both from the prestigious IU Graduate School. Both programs provide the latest instruction, hands-on laboratory courses and an interactive, problem-based learning experience. http://www.iupui.edu/~solctr/research/details.php?id=221 The focus of the Bowen Research Center is health policy and health services research. The Center\'s multi-million dollar research program provides research opportunities for faculty and students from both schools, as well as collaborative research efforts nationally and internationally. The Center is the first institution of its kind solely dedicated to primary care in preventing \"lifestyle\" diseases. Primary care (the physician a patient first sees--family practitioners, internists, obstetricians, and pediatricians) is essential to improving America\'s health and reducing its health-care costs. The Center addresses primary-care issues in three major areas of interest: preventive medicine, rural health care, and health-care cost containment. http://www.iupui.edu/~solctr/research/details.php?id=222 The Cancer Center Clinical Research Office provides essential services that enable the clinical investigator to efficiently conduct trials in cancer. It supports the coordination of the Cancer Center Protocol Review and Monitoring System, the submission to and review of protocols by the Cancer Center Scientific Review Committee, the training and supervision of research staff, and the maintenance of computerized databases to track protocols and patient data. http://www.iupui.edu/~solctr/research/details.php?id=223 The Cardiovascular Physiology Core provides technical and model support for rodent studies. http://www.iupui.edu/~solctr/research/details.php?id=224 The mission of the Center for Alzheimer Disease and Related Disorders is to provide multi-disciplinary, high-quality, comprehensive clinical, research, and educational services to elderly individuals and families with memory loss and/or mood disorders. http://www.iupui.edu/~solctr/research/details.php?id=225 The Center for Art, Design and Public Life serves as the primary interface between Herron School of Art and Design, IUPUI and the community. Its purpose is to involve students, faculty and staff in meeting community needs related to professional design practice, fine art projects, public art project management and visual art and design internships. The center\'s mission is to create community partnerships based on creative practices that serve the Herron community and the diverse populations of Indianapolis and beyond. http://www.iupui.edu/~solctr/research/details.php?id=226 The mission of the Center for Computational Biology and Bioinformatics is to bring cutting-edge research in these areas to Indiana University, with special emphasis on the problem of identifying the functions for the various genomic entities and in a manner that stimulates collaborations. http://www.iupui.edu/~solctr/research/details.php?id=227 The Center\'s goal is to have all Indiana schools meet or exceed the Voluntary National Content Standards in Economics so that all students will leave school with a basic understanding of economics and the problem solving skills needed to become prosperous workers, consumers, and citizens in the next century. To meet these goals the IUPUI Center for Economic Education and the Indiana Council for Economic Education strive to increase the economic understanding and decision making skills of students by providing educators with a basic understanding of economics, teaching strategies, and curriculum materials which are objective and consistent with state and national educational guidelines. http://www.iupui.edu/~solctr/research/details.php?id=228 CEQL is composed of three core areas: the administrative core, the biostatistics core, and the research development and dissemination core. CEQL\'s overall goal is to advance knowledge related to improving the health-related quality of life (HRQL) in persons with chronic conditions across the life span. http://www.iupui.edu/~solctr/research/details.php?id=331 The mission of the Indiana University Center for Environmental Health is to foster excellence in scientific research, training, and outreach in environmental health with a goal of identifying, understanding and preventing environmentally related diseases covering the human life span. Locally, environmentally driven human disease costs the State of Indiana jobs and potential revenue, and negatively impacts the quality of life and the economy of the State. The IU School of Medicine and IUPUI campus provide an ideal setting for coordinated effort in Environmental Health Sciences. The combination of academic health science research, environmental research, county and state public health programs, state environmental programs, information technology, and centers for environmental policy and earth and environmental science are all located on or near the IUPUI campus. Thus this location provides an excellent geographic and philosophical template to foster understanding and improving human health and the environment. The goal of the Center is to be a nationally and internationally recognized center for Environmental Health. http://www.iupui.edu/~solctr/research/details.php?id=231 The Center for Immunobiology studies immune factors that affect growth, development, and the health of the human body. The center brings together expertise of researchers from various basic science disciplines, allowing for a focus on research that will translate into better therapies and care for patients. http://www.iupui.edu/~solctr/research/details.php?id=232 The CICL coordinates and supports all international programs and activities at the law school.Programs and activities include: the Master of Laws (LLM) program, the summer study abroad programs, various student and faculty exchange programs, as well as a number of contract research and service programs abroad. http://www.iupui.edu/~solctr/research/details.php?id=234 The long-term goal of the Center for Medical Genomics at the Indiana University School of Medicine is to improve health by facilitating cutting-edge research with state-of-the-art genomic technologies for studying gene expression and genetics. The center provides experimental design, infrastructure, and consulting services for use of genomic technology in studies of disease and in other biomedical research. The CMG is a full-service Affymetrix core facility that can utilize both expression arrays and genotyping arrays. It also has a high-throughput SNP genotyping facility. Both are supported by bioinformatics infrastructure. http://www.iupui.edu/~solctr/research/details.php?id=235 The mission of the Center for Service and Learning (CSL) is to involve students, faculty, and staff in service activities that mutually benefit the campus and community. The four offices in CSL are: Office of Service Learning which assists faculty in the design and implementation of service learning classes and involves students in organized community service activities as a part of an integrated aspect of IUPUI courses; the Office of Community Service which coordinates programs to promote and recognize the involvement of IUPUI students, faculty, and staff in the local community through community service events; the Office of Neighbrohood Partnerships which collaborates with community organizations and other campus units to build long-term partnerships between IUPUI and its surrounding neighborhoods; and the Office of Community Work-Study which coordinates tutoring programs that train and place IUPUI work-study students in area schools and community centers to assist pre-school through sixth grade youth in reading and math and also places IUPUI work-study students in community service positions at government and nonprofit organizations and agencies. CSL also coordinates the Sam H. Jones Community Service Scholarship Program that recognizes students for previous service contributions to their high schools, campus, or community. http://www.iupui.edu/~solctr/research/details.php?id=339 The mission of the Center for Sports Medicine is to provide a unique approach to treating exercise and sports-related injury. The vision is to combine innovative, individualized treatment with cutting edge technology and national educational leadership in exercise and sports medicine. http://www.iupui.edu/~solctr/research/details.php?id=229 Additional information coming soon. http://www.iupui.edu/~solctr/research/details.php?id=236 The Center for Structural Biology is a multidisciplinary center whose researchers examine structural characteristics of biological macromolecules and how changes in properties relate to specific diseases. Services include Surface Plasmon Resonance (BiaCore Instrument) and x-ray crystallography. http://www.iupui.edu/~solctr/research/details.php?id=230 The Center for Teaching and Lifelong Learning (CTLL) supports the school's mission of developing a community of learning by emphasizing superior and innovative teaching and lifelong learning. CTLL offers a variety of services, faculty development, peer review, instructional product development and testing. In addition, we support, recognize, and advance the scholarship of teaching, disseminating knowledge and best practices in nursing education and healthcare worldwide. http://www.iupui.edu/~solctr/research/details.php?id=237 The Center for the Study of Religion and American Culture is a research and public outreach institute devoted to the promotion of the understanding of the relation between religion and other features of American culture. http://www.iupui.edu/~solctr/research/details.php?id=238 The Center for Urban and Multicultural Education (CUME) is the research arm of the Indiana University School of Education (SOE) at IUPUI, with the mission of creating connections of research, practice, and educational improvement for city schools and urban communities. CUME primarily encompasses research and evaluation that can lead to improved practices, assessment, leadership, policy, and community engagement for urban schools, where many of the nation\\\'s poor children and children from cultural and linguistic minority backgrounds are educated. CUME supports four interrelated research networks, each comprised of faculty and community stakeholders who design research and study issues affecting city schools: School-Community Engagement and Building Civic Capacity Educational Leadership and School Transformation Diversity/Culture, Learning, and Teaching and Performance Assessment of Student Learning. http://www.iupui.edu/~solctr/research/details.php?id=239 This applied research center is devoted to supporting economic success for Indiana and a high quality of life for all citizens. Center researchers work with community leaders, business and civic organizations, nonprofits, and state and local governments to analyze options and develop strategies that can benefit communities. The center conducts ongoing research on public policy, economic development, health policy, criminal justice, public safety, nonprofits, gaming, land use, and Central Indiana. It also partners with other organizations to investigate topics that have ranged from property tax to riverboat gambling, neighborhood empowerment, the economic impact of the arts and sports, and drinking water and sewer infrastructures. http://www.iupui.edu/~solctr/research/details.php?id=240 The goal of the Center of Excellence in Computational Diagnostics is to develop blood tests to better identify disease biomarkers for pediatric cancer and heart disease. http://www.iupui.edu/~solctr/research/details.php?id=241 The Center on Philanthropy at Indiana University increases the understanding of philanthropy, improves its practice, and enhances participation in philanthropy through programs in research, teaching, public service, and public affairs. The Center on Philanthropy collaborates extensively with local and state nonprofit organizations and provides them with fundraising, board governance and other training through its programs such as The Fund Raising School, the Women\'s Philanthropy Institute, and other professional development offerings. It assists citizens, policymakers, nonprofit professionals and others in understanding and assessing the vital role Indiana\'s nonprofits play in Hoosier\'s daily lives by conducting research on critical issues. For example, the Indiana Nonprofit Scope and Community Dimensions project examines nonprofits\' impact on the state\'s employment and economy, and the demographics, management, and accountability of local nonprofits. The Indiana Gives report details how and how much Hoosiers give and volunteer for charitable causes. Nonprofit and other organizations contract with the Center to analyze the dynamics of changes taking place, assess the philanthropic environment and evaluate their programs. The Center on Philanthropy offers Central Indiana nonprofits additional resources in the form of talented students versed in the latest research and professional nonprofit techniques. Internships and graduate assistantships strengthen local nonprofits while giving students hands-on experience. http://www.iupui.edu/~solctr/research/details.php?id=242 The Center on South East Asia provides an interdisciplinary and intercampus approach to university activities that relate to Southeast Asia and that build on strong social science and professional education traditions. The center will promote outstanding educational, economic, and cultural programs between Indiana University and institutions in Southeast Asia by encouraging and supporting educational and training projects, research, student overseas study, partnerships, business development, and information resources that share the strengths and advantages of each region. For the purposes of the center, Southeast Asia includes the countries of Australia, Brunei, Burma, Cambodia, Indonesia, Laos, Malaysia, the Philippines, Singapore, Thailand, Vietnam, and New Zealand. http://www.iupui.edu/~solctr/research/details.php?id=336 Indiana Children Health Services Research is a research section of the Department of Pediatrics at IU School of Medicine. Our mission is to improve the health and health care of children by developing and applying best scientific evidence methods in health services research and informatics. http://www.iupui.edu/~solctr/research/details.php?id=243 This laboratory is developed to conduct research in combustion and advanced propulsion. Researchers in the lab can perform pulsed and steady combustion experiments with exhaust system and low-vibration optics capability. The laboratory houses a Flame Diagnostics Facility for multiple diagnostics on flames with applications in fire safety and combustion emissions. Diagnostic methods include high-resolution digital photography, laser extinction and scattering, image processing and temperature sensing. The laboratory includes a Non-Steady Combustion and Flow Facility with rotating-seal multi-tube rigs for advanced combustion engines, including wave rotor sealing studies, pulsed combustion and gas dynamics, ejector flows and shock-driven events. The laboratory also conducts projects related to diesel engines in the area of engine cooling and waste heat recovery systems. These projects aid in the development of advanced engines with low emission and high efficiency as mandated by the EPA. The facility supports research in advanced non-steady engines and propulsion systems that are being developed in collaboration with NASA, engine industries, and Purdue Zucrow Laboratory. http://www.iupui.edu/~solctr/research/details.php?id=244 The mission the IUPUI Community Learning Network (CLN) is to raise educational achievement by meeting the educational and training needs of learners at times and places that are convenient for life-long learning. CLN offers both credit and continuing studies noncredit classes at corporate locations, in community centers, in high schools, at Glendale Mall, at the Community Life and Learning Center in Carmel, and in a virtual environment through the Internet, public television, videotape, CD, or DVD. http://www.iupui.edu/~solctr/research/details.php?id=245 The mission of this laboratory is to conduct research and develop software in the areas of computational fluid dynamics and heat transfer related areas for large-scale problems. Faculty, research staff and graduate students in this laboratory have been conducting externally funded research in large-scale and parallel computing of high and low speed fluid dynamics problems, including multidisciplinary applications. Current research projects include solutions of three-dimensional flow problems, high speed compressible flow calculations for internal and external flows, unsteady flow computations, Grid computing, parallel computing, solid-fluid interactions, and dynamic load balancing for parallel computing on parallel processors and network of workstations. Other research projects include the design and simulation of pulse detonation engine and wave rotor non-steady flow cycle, simulations of urban wind effect and pollutant/hazardous gas dispersion, and transient flow and combustion calculations. It has received substantial support from NASA Glenn Research Center for the last twenty years. The laboratory is equipped with a Local Area Network (LAN) consisting of a cluster of Unix and Linux workstations and a Wide Area Network (WAN) including IUPUI and Indiana University IBM SP2 computers and Linux clusters, as well as Linux clusters of NASA Glenn Research Center. These networks provide a heterogeneous test-bed for the computing algorithms developed in the laboratory. http://www.iupui.edu/~solctr/research/details.php?id=246 The Computational Molecular Science Facility, at Indiana University-Purdue University Indianapolis, has a mission to support the School of Science faculty, students and staff as well as other IUPUI research professionals in their research pursuits. The Computational Molecular Science Facility focuses on maintaining state of the art hardware and software addressing the broad computational and modeling needs of molecular scientists, together with up-to-date molecular modeling instruction, advice, and support. http://www.iupui.edu/~solctr/research/details.php?id=387 The Confucius Institute in Indianapolis is an apolitical, non-profit organization. It was established at IUPUI in 2007 to promote the teaching of Chinese language and culture in central Indiana and to facilitate mutual understanding between the peoples of China and United States. http://www.iupui.edu/~solctr/research/details.php?id=247 The mission of this laboratory is to assist IUPUI in becoming one of the national leaders in the effective and creative use of information technology in teaching, learning and distributed education. As specialists in information technology, CyberLab staff and interns conduct and apply research and development techniques to bring new educational opportunities to teaching and learning. Over the years, the research team of this lab developed multimedia and electronic instructional tools such as Mipsit, IMDS, Oncourse, Angel, ePortConsortium, and Epsilen. http://www.iupui.edu/~solctr/research/details.php?id=248 The mission of this laboratory is to support a wide range of mechanical and physical property testing. Expertise in adhesive dentistry, ceramic fabrication and failure analysis, and ADA/ANSI - ISO Specification testing can be found. The laboratory conducts research testing for researchers from other research institutions and industry. http://www.iupui.edu/~solctr/research/details.php?id=249 The research activities in the DeVault Otologic Research Laboratory currently are directed at defining the benefits that hearing-impaired children derive from different sensory aids. A major focus of the research is detailed investigation of changes in speech production, speech perception, language, and cognitive skills after profoundly deaf children receive a cochlear implant. http://www.iupui.edu/~solctr/research/details.php?id=250 The mission of this facility is to provide microanalyses of mineralized tissues such as teeth and bone and virtually all solid materials with Electron probe micro analyzer (EPMA). The facility is involved in research that requires large amounts of biological analysis using Secondary and Backscattered Electron Microscopy. Preparation for biological, geological, and material specimens is also available upon request. The Digital Electron Microscopy Facility (DEMF) is located at the IU School of Dentistry on the IUPUI campus. We are a recently renewed facility equipped for imaging surface microstructures and mapping micro-chemical characteristics of a wide variety of biological and solid material specimens. The facility is accessible to researchers and scientists throughout the Midwest, and collaborations that will challenge our capabilities. The purchase of the SEM and EPMA instruments was made possible by financial support from the National Science Foundation under Grant No. 9871243. http://www.iupui.edu/~solctr/research/details.php?id=251 The DNA Bank and Cell Repository offers molecular genetics services, including DNA and RNA extraction and storage, lymphocyte immortalization and storage, and a variety of tests for the University and community at large. http://www.iupui.edu/~solctr/research/details.php?id=252 CEES is a research center working to solve complex environmental problems and translate environmental issues and solutions to legislators, environmental professionals, students, and citizens. Research crosses traditional science boundaries and includes: Wetland Ecosystem Restoration, The Fate and Transport of Environmental Contaminants, Water Resource Evaluation and Environmental Data Management and Visualization. http://www.iupui.edu/~solctr/research/details.php?id=253 The Electron Microscopy Center is a full service research laboratory providing both transmission and scanning electron microscopy. The center can provide technical services to help design and then implement experiments needing either type of microscopy. The service provided can apply both traditional methods and more recent technical developments to suit the investigator\'s needs. http://www.iupui.edu/~solctr/research/details.php?id=254 The Flow Cytometry Resource Facility provides essential flow cytometric services as well consultation and technical advice. The facility is capable of performing virtually any flow cytometric assay, from multiparameter immunofluorescence analysis and cell sorting to DNA content and cell cycle analysis. The mission of this facility has been to serve the varied research needs of researchers at the IU Cancer Center. http://www.iupui.edu/~solctr/research/details.php?id=255 The Frederick Douglass Papers Project collects and publishes the writings of the great nineteenth-century, African American, anti-slavery and human rights activist Frederick Douglass. http://www.iupui.edu/~solctr/research/details.php?id=256 The General Clinical Research Center (GCRC) is the School of Medicine\'s major clinical resource for supporting faculty who have Public Health Service funding for patient research. GCRC staff are highly experienced and specially trained in patient research. They provide the support necessary for the execution of a wide variety of patient studies in both adults and children. Services include nursing, nutrition, biostatistics, computing, laboratory, and administration. The GCRC is open 24 hours/day, 7 days/week and is equipped with inpatient and outpatient facilities. http://www.iupui.edu/~solctr/research/details.php?id=257 Promotes the value and importance of geography in Indiana Schools. Provides a forum where teachers can exchange ideas. Encourages an excellence in the teaching of geography through classroom techniques. http://www.iupui.edu/~solctr/research/details.php?id=258 The Herman B Wells Center for Pediatric Research, which opened in 1991, provides state-of-the-art bench laboratory space and the supportive infrastructure for interactive basic science and clinical research. The goal of research in the Wells Center is to improve the understanding and treatment of devastating diseases which affect children. The Wells Center also provides an outstanding training environment for medical and graduate students, residents, and fellows. Research programs include those in blood cell development and genetic blood cell diseases, cancer biology, gene therapy, growth and metabolism, cardiopulmonary physiology and development, and asthma. The Center was developed through the efforts of the Department of Pediatrics and the Riley Children’s Foundation, and is named for Herman B Wells, Chancellor of Indiana University, a 50-year member of the James Whitcomb Riley Memorial Association and a beloved friend of children who symbolizes for all of Indiana the spirit of caring and of life-long dedication to the pursuit of excellence. http://www.iupui.edu/~solctr/research/details.php?id=259 The Human Expression Core provides assistance with measuring phenotypes, banking human biological material, and maintaining and accessing repositories of human phenotype/genotype data. http://www.iupui.edu/~solctr/research/details.php?id=260 The mission of the laboratory is to conduct both basic and applied research in sports medicine and biomechanics and to expose undergraduate and graduate students to research in the exercise sciences. The laboratory houses metabolic carts, treadmills, bike ergometers, force platforms, isokinetic dynamometers, motion analysis systems, and other pertinent equipment and software. http://www.iupui.edu/~solctr/research/details.php?id=307 The four-fold mission of the Program in International Human Rights are: 1)to further the teaching and study of international human rights law at the law school; 2? to promote scholarship in international human rights law; 3) to assist human rights governmental, inter-governmental, and non-governmental organizations on international human rights law projects; and 4)to facilitate student placements as law interns at domestic and overseas human rights organizations. http://www.iupui.edu/~solctr/research/details.php?id=261 The mission of the Center is to conduct research in the causes, diagnosis, treatment, and prevention of high blood pressure and its complications. http://www.iupui.edu/~solctr/research/details.php?id=262 The Indiana AIDS Clinical Research Group evaluates therapeutic modalities for their efficacy against HIV infection in humans and investigates the complications of HIV infection and HIV therapeutics. http://www.iupui.edu/~solctr/research/details.php?id=263 The Indiana Alcohol Research Center (ARC) is a n NIH-funded specialized research center (P60) that focuses on the elucidation of the biomedical and psychosocial factors that contribute to alcohol abuse and alcoholism. Scientific researchers in the ARC are in the process of determining the biological and molecular basis for differences in the way people drink, and the consequences of heavy drinking. It provides selectively bred animals differing in alcohol preference as models of genetic predisposition to alcoholism, performs genotyping of enzymes of alcohol metabolism to assess the role those genes have in responses to alcohol, and is establishing proteomic services for alcohol researchers. The center is also highly involved in educating Indiana policy makers regarding the science behind diagnosis and treatment of alcoholism and other substance abuses, and in the training of health sciences students about the biology and social aspects of substance abuse. http://www.iupui.edu/~solctr/research/details.php?id=264 The purpose of the Indiana Alzheimer Disease Center is to identify persons with probable Alzheimer disease. The center\'s research involves patients with Alzheimer disease and other related senile dementias as well as a comparison group of healthy older adults. http://www.iupui.edu/~solctr/research/details.php?id=265 An information outreach service of the Kelley School of Business, the IBRC provides and interprets the economic and demographic information needed by the state\'s business, government and nonprofit organizations, as well as users of such information throughout the nation. The Center maintains detailed databases on numerous topics such as income, employment, taxes, activity in different sectors of the economy, education, demographics and a host of other indicators for the nation, the state and local areas. In addition, the Center conducts original research to generate needed information when existing data are not available or sufficient. These data are subjected to sophisticated analyses to provide insight into current conditions and trends that will shape the future. Clear, understandable presentation of research findings, with a focus on implications for action, is an IBRC hallmark. Policy makers in both public and private sectors turn to the IBRC to enlighten key issues they face. http://www.iupui.edu/~solctr/research/details.php?id=266 The microscopy center is a light microscopy core facility that provides state-of-the-art imaging capabilities to Indiana University researchers. The mission of the center is to enhance the quality of research and the competitiveness of grant applications from Indiana University investigators by: 1) providing ready access to state-of-the-art imaging equipment that would be impractically expensive for individual laboratories 2) providing a level of imaging expertise that guarantees effective exploitation of the imaging technologies of the center 3) adapting center instruments to maximize their productive utilization by investigators regardless of their microscopy or computer expertise 4) enhancing the productive utilization of the center through a program of education, including seminars, courses, and individual training and 5) developing and disseminating new methods of microscopy and digital image analysis appropriate to biomedical research. The center provides high resolution confocal epifluorescence and multiphoton microscopy of cells, tissues and organs in living animals and fixed samples, and development of methods for imaging and digital image analysis. http://www.iupui.edu/~solctr/research/details.php?id=267 The Indiana Center for Intercultural Communication, ICIC, is a university-based research and service organization created to facilitate the expanding global linkages of the city of Indianapolis and the state of Indiana by developing and extending expertise in Intercultural Communication and Language for Specific Purposes. http://www.iupui.edu/~solctr/research/details.php?id=268 The ICRSER is a permanent collaboration among strategic partners whose combined expertise in health care, science, engineering, and technology is designed to create a powerful, focused infrastructure in Indiana to acquire grants and contracts for conducting rehabilitation science and engineering research to improve the mobility of persons with current or potential musculoskeletal disabilities, to strengthen Indiana's world-class medical device industry, and to improve employability and quality of life of people who suffer from disabling conditions related to mobility. The founding partners include 7 Schools on the IUPUI campus, the Rehabilitation Hospital of Indiana, and the Richard L. Roudebush Veterans Administration Medical Center. There are numerous statewide corporate, technology and university affiliates such as Cook Biotech, Inc., TechPoint, Purdue University's Discovery Park and Ball State University's Human Performance Laboratory. http://www.iupui.edu/~solctr/research/details.php?id=269 The Indiana Center of Vascular Biology and Medicine (ICVBM) is committed to being a leader in basic as well as applied research in understanding mechanisms of vascular wellness and disease, and the development of leading-edge medical therapies to improve the care of patients with vascular problems. The overall mission of the ICVBM is the rapid development and extension to clinical application and commercialization of new knowledge in vascular biology. The ICVBM thus operates with the purpose of facilitating research while impacting delivery of novel and innovative medical treatment in order to achieve positive results within the health care community. http://www.iupui.edu/~solctr/research/details.php?id=270 The Indiana Center of Excellence in Biomedical Imaging serves the academic, medical, and business communities of Indiana as: 1) a focal point for multi-institutional collaboration in basic and applied research to develop novel biomedical imaging modalities, and for related technology transfer to the private sector 2) a resource providing state-of-the-art biomedical imaging technologies in support of academic and private-sector research initiatives and 3) a centralized site for compounding of radiopharmaceuticals that will be distributed for clinical use in a statewide network of hospitals and diagnostic imaging centers. http://www.iupui.edu/~solctr/research/details.php?id=271 The mission of Indiana Children\'s Health Services Research is to improve the health and health care of children by developing and applying best scientific evidence and methods in health services research and informatics. http://www.iupui.edu/~solctr/research/details.php?id=272 The mission of the Indiana Spinal Cord and Head Injury Research Center is to provide the most current, best standards of care to patients with head and spinal cord injuries and to develop a treatment program that is based on stem cells, trophic factors, and inhibiting proteins that are known to block the regeneration of tissues destroyed by spinal cord injuries. http://www.iupui.edu/~solctr/research/details.php?id=273 The Indiana University Breast Care and Research Center, designed to help detect breast cancer, conduct research, and encourage collaboration among all breast care specialists, offers a multi-disciplinary approach to diagnosis and treatment. Research is underway to provide improved therapies to women suffering from early and later stages of breast cancer. The center provides women with any type of breast problem, from breast pain to malignancy, comprehensive diagnostic services, specialty consultations, and multidisciplinary treatment planning in a single visit. http://www.iupui.edu/~solctr/research/details.php?id=275 The mission of the Indiana University Center for Aging Research is to improve the quality of life for older adults through interdisciplinary research. To carry out its mission, the center\'s scientists conduct investigations to test innovative strategies to improve the quality of health care and self-care for older adults. http://www.iupui.edu/~solctr/research/details.php?id=276 The Indiana University Center for Bioethics has a broad mandate to conduct research, engage in education, and provide service to the Indiana University community relating to bioethics. http://www.iupui.edu/~solctr/research/details.php?id=277 The mission of the Center is to advance the science of transforming the health care system, locally, regionally and nationally. The Center was established in 2003 through funding from Indiana University and the Regenstrief Institute, Inc. There are currently 16 faculty researchers (MD and PhD) whose primary academic mission fits within this Center. Our vision is to become the leading national research resource for learning about health system transformation. Our strategy is to partner with managers, clinicians, patients and other researchers in interdisciplinary teams to innovate, foster system redesign and drive broad scale adoption of changes to improve care delivery. Within this overall mission and vision, our research priorities are to: 1) organize health services, management and engineering researchers at IUPUI and Purdue into a cohesive research and development center; 2) provide infrastructure and synergies to lower the costs of health care systems redesign, implementation and dissemination; 3) react quickly and aggressively to provide high quality service and pursue extramural funding opportunities to improve health care in Indianapolis, the state of Indiana and the Midwest; and 4) foster effective research partnerships with local and regional healthcare systems, healthcare organizations, government, other academic entities, and industry on the IUPUI campus and in Indiana. Faculty of the IU CHSOR and Roudebush VAMC were recently designated a VA Health Services Research and Development (HSR&D) Center of Excellence in Implementing Evidence-based Practice (CIEBP), see www.ciebp.research.va.gov). We have collaborations with over 50 investigators from a broad range of disciplines and partnerships with over 15 schools and centers at IUPUI and Purdue. Core research development activities include leading the IU NIH K30 Clinician Investigator Training Enhancement program, key partners in the Indiana Patient Safety Center, and participating in the Indiana Genomics Executive Committee, the Indianapolis Coalition for Patient Safety, Indiana Medicaid, Indiana Mental Health Association, and others. IU CHSOR is one of the three programs of the Regenstrief Institute, Inc. We are strategic partners with the IU School of Medicine, IUPUI, Purdue University, Regenstrief Center for Healthcare Engineering, and the VA Center of Excellence in Implementing Evidence-based Practice. Our center investigators direct the Indiana Assertive Community Treatment (ACT) Center (Dr. Salyers) and the IUPUI Center for Assessing, Understanding and Managing Pain (Drs. Bair and Kroenke). http://www.iupui.edu/~solctr/research/details.php?id=333 I. Utilize advanced imaging technologies to further the understanding of brain structure & function in healthy individuals and clinical populations, as well as in translational animal models. II. Investigate the relationship between genetic variations and phenotypic expression structurally and functionally in health, illness, and following treatment. III. Provide training & experience in functional and morphometric neuroimaging research. IV. Develop, assess, and validate emerging technologies: optimize the use of molecular and functional imaging methodologies including PET, fMRI, DTI, MRS, perfusion and morphometry including image processing strategies. http://www.iupui.edu/~solctr/research/details.php?id=278 The center\'s key objective is to improve the quality of life for persons with diabetes through education of healthcare professionals and patients. The Indiana University Diabetes Center is the only comprehensive care center in Indiana that offers education, research, exercise, and treatment programs for diabetes patients of all ages, including pregnant women with gestational diabetes. Research is currently underway to develop pancreatic islet cell transplantation for patients suffering from early onset insulin-dependent diabetes. http://www.iupui.edu/~solctr/research/details.php?id=274 The Indiana University Cancer Center is a National Cancer Institute designated cancer center. Indiana University Cancer Center advances the understanding, prevention and treatment of cancer throughout Indiana and the world with patient centered care, acceleration of promising science and collaborative educational programs. Its goals are to: 1) foster excellence in interdisciplinary translational research through established and developing research programs, 2) provide the highest quality patient care through interdisciplinary clinical programs, 3) Develop nationally recognized interdisciplinary graduate and post-graduate education and training programs, and 4) Facilitate the development and implementation of a statewide cancer control program. http://www.iupui.edu/~solctr/research/details.php?id=279 The Indiana University Vector Production Facility is a campus-wide resource that provides gene transfer expertise for research and clinical gene transfer projects. The charge of the IU VPF is to provide investigators with state-of-the-art gene transfer reagents, molecular diagnostic services, and scientific and regulatory support. This laboratory has been designated a National Gene Vector Laboratory by the National Institutes of Health. http://www.iupui.edu/~solctr/research/details.php?id=280 The Informatics Research Institute conducts research in areas of emphases shared with the School of Informatics, including fundamental research in human computer interaction; fundamental research in capturing, managing, analyzing, and explaining information and in making it available for its myriad uses; expanding research into policy and socioeconomic issues arising from information technology and informatics applied to various subject areas such as Health, Biology, Chemistry, and Fine Arts. http://www.iupui.edu/~solctr/research/details.php?id=329 CityNet is a World Health Organization (WHO), Collaborating Center in Healthy Cities. Our Mission is to provide information that will encourage communities to build a safe and healthy environment within urban areas. http://www.iupui.edu/~solctr/research/details.php?id=282 The Institute is a unique research facility bringing to IUPUI and to Central Indiana an internationally acclaimed concentration of resources and scholarship that focuses on fundamental strongholds of American thought and culture. The Institute unites the teaching faculty, editing specialists, and research holdings of the Peirce Edition Project, the Santayana Edition, and the Frederick Douglass Papers, and the Ray Bradbury Project (see Collections for information on these projects) with related academic programs in American Studies, Professional Editing, and American philosophy. http://www.iupui.edu/~solctr/research/details.php?id=338 The Institute for Family and Social Responsibility is a joint effort of the School of Public and Environmental Affairs and the School of Social Work, with a primary focus on social policy research and outreach activities. The Institute\'s mission is to bring together the resources of citizens, governments, communities and Indiana University to better the lives of children and families. Ongoing research projects examine the impacts of welfare reforms, the adequacy of child support guidelines, community responses to the Temporary Assistance to Needy Families legislation, and AIDS education for incarcerated youth. The Institute serves as the National Child Support Enforcement Research Clearinghouse. It also administers a university-wide competitive student internship program in collaboration with the Indiana Family Social Service Administration. http://www.iupui.edu/~solctr/research/details.php?id=283 The Department of Psychiatry\'s basic science research effort is centered at the Institute of Psychiatric Research. The Institute, as an integral part of the Department, shares the mission of the Department to understand and treat severe neuropsychiatric disorders, with schizophrenia, affective disorders, dementia, substance abuse, anxiety disorders, and developmental disorders being the major examples. The Institute has particular strength in neurochemistry, neurophysiology, genetics, and the behavioral sciences. http://www.iupui.edu/~solctr/research/details.php?id=284 Intelligent Control and Sustems Laboratory in the Department of Electrical and Computer Engineering of Purdue School of Engineering and Technology, IUPUI, involves many faculty members, post-doctoral research associates, and graduate and undergraduate students from the department of Electrical and Computer Engineering, Mechanical Engineering, and Computer and Information Sciences. The areas of research include modeling, simulation, optimization, and advanced control of complex systems such as electromechanical systems, biological systems, power systems, and transportation systems; intelligent control and automation; computational intelligence (neural networks, fuzzy logic, genetic algorithms) and its applications; and advanced hybrid vehicle technologies. The research programs have been sponsored by federal and state agencies such as NSF, DARPA, US Army, ONR, Indiana State 21st Century Fund, as well as private companies. http://www.iupui.edu/~solctr/research/details.php?id=285 The mission of the IRRL is to perform cutting-edge research on minimally invasive therapies. Its goals are to: 1) support the research activities of interventional radiology faculty at IU Medical Center 2) serve as a core facility to provide angiography, surgery, and molecular physiology support to other departments at Indiana University and 3) support the pre-clinical development of new devices and therapies that may lead to less invasive and more efficacious therapies. http://www.iupui.edu/~solctr/research/details.php?id=334 IUPUI business assistance center that utilizes faculty and student expertise to offer assessments and recommendations on network and data security as well as optimization of hardware and system software configurations to Indiana\'s small businesses and nonprofit organizations. http://www.iupui.edu/~solctr/research/details.php?id=337 The goal of the center is to support a multi-disciplinary environment that promotes basic, clinical, epidemiologic, behavioral, and translational research in the prevention, detection, and treatment of HIV infection and AIDS, both at home and in developing countries. http://www.iupui.edu/~solctr/research/details.php?id=319 The IUPUI Solution Center serves as a single point of access to campus resources to develop partnerships, create professional internships, link the community and faculty, and customize programs and research for community clients. http://www.iupui.edu/~solctr/research/details.php?id=286 Research at the internationally recognized Krannert Institute of Cardiology includes studies ranging from molecular mechanisms to clinical treatments in a wide range of cardiac-related problems. Major areas of emphasis include cardiac electrophysiology and arrhythmias, cardiac ultrasound, vascular biology, heart failure and transplantation, interventional cardiology, regeneration, and the repair of cardiac muscle and cardiac cell proteins. Integration between basic and clinical research is the hallmark of this institute. http://www.iupui.edu/~solctr/research/details.php?id=287 This laboratory provides immunohistochemistry and histology services on IACUC-approved animal studies and IRB-approved research of human tissues. http://www.iupui.edu/~solctr/research/details.php?id=288 Walther Cancer Institute\'s mission is to eliminate cancer as a cause of suffering and death by conducting research into the prevention, causes and cures of the many forms of the disease. The Mary Margaret Walther Program focuses on research that involves human behavior and the adaptation that patients and families make to cancer. The mission of the Mary Margaret Walther Program is to increase cancer prevention/control, improve quality of life, and improve comprehensive palliative care. http://www.iupui.edu/~solctr/research/details.php?id=289 Affiliated with the Institute for American Thought, the mission of the Center is to support German American Studies through research, teaching, and service. German-American Studies is generally defined as the study of the German diaspora to America and its effect on American culture and society. The study of German-American relations in general also falls under the purview of the Center\'s activities. http://www.iupui.edu/~solctr/research/details.php?id=290 Medical Informatics is an Indiana Genomics Initiative program housed in the Regenstrief Institute that provides an advanced information infrastructure for medical research in Indiana. This program provides the clinical information necessary to understand the complex relationships underlying cancer, heart disease, and other medical conditions. The Regenstrief Medical Record System (RMRS), one of the nation\'s first electronic medical record systems, contains data collected from all Indianapolis hospital systems. RMRS has been widely recognized for its role in improving quality of care, increasing efficiency of healthcare delivery, preventing medical errors, and enhancing patient safety. Regenstrief informaticians created the first citywide electronic medical records system in the U.S., which allows physicians in emergency departments, with the patient\'s permission, to view a single virtual record of all previous care at any of 11 participating hospitals. They also developed the Logical Observation Identifiers Names and Codes (LOINC) system, a standard nomenclature that enables the electronic transmission of clinical data from laboratories that produce the data to hospitals, physicians\' offices, and payers who use the data for clinical care and management purposes. http://www.iupui.edu/~solctr/research/details.php?id=291 This core provides a stockroom for scientific supplies. http://www.iupui.edu/~solctr/research/details.php?id=292 The mission of the Midwest Center is to promote evidence-based practices in psychiatric rehabilitation throughout Indiana and the surrounding states. Our long-term goals center on promoting EBP though (1) research on effectiveness of both established and emerging EBPs, including both randomized controlled trials of their clinical and cost effectiveness, as well as fidelity of program implementation, (2) research on the barriers to implementation of EBPs and strategies to overcome these, (3) training and consultation to mental health agencies and their staff on the most effective practices and how best to implement those practices. Short-term goals of the center include: (1) state-wide implementation of assertive community treatment in Indiana, facilitated by the efforts of the ACT Center of Indiana, (2) promotion of effective interventions in routine mental health treatment settings, through collaboration with the National Implementing Evidence-Based Practices Project. http://www.iupui.edu/~solctr/research/details.php?id=293 The Midwest Sexually Transmitted Infections and Topical Microbicides Cooperative Research Center (Midwest STI TM CRC) is a consortium agreement between Indiana University and Northwestern University. The Midwest STI TM CRC, which was renewed by NIH through 2009, is one of six STI TM CRCs in the United States, and one of three CRCs that have been continuously funded since the program began in 1991. Two IU projects center on STIs in a cohort of 14 to 24-year-old women. One (Dr. Fortenberry) focuses on developmental factors influencing the acquisition of STIs, while another (Dr. Zimet) assesses vaginal microbicide acceptability across adolescence and young adulthood. A third IU project (Dr. Spinola) performs experimental infections with Haemophilus ducreyi in human volunteers to address the pathogenesis of chancroid and interactions between H. ducreyi and HIV. The projects are supported by administrative, biostatistical, clinical, and laboratory cores. The Midwest STI TM CRC represents the collaborative strengths of infectious diseases, adolescent medicine, biostatistics, and microbiology and immunology. http://www.iupui.edu/~solctr/research/details.php?id=294 The research activities in this Lab are focused on digital signal processing and multimedia applications including image processing, digital video, and visual communications. It is equipped with the state-of-the-art DSP software and hardware development tools sponsored by Motorola. It also features a communications laboratory integrated simulation system. Research areas include developing error resilient rate scalable image and video compression techniques for transmission across data networks, developing error concealment techniques for the transmission of compressed images and video over data networks and wireless networks, developing image enhancement and restoration techniques for medical imaging applications, secure transmission over images and video over data networks, and developing image segmentation techniques. http://www.iupui.edu/~solctr/research/details.php?id=295 The mission of the Multipurpose Arthritis and Musculoskeletal Diseases Center is to pursue major biomedical research interests relevant to the rheumatic diseases. Current areas of emphasis include articular cartilage biology, pathogenesis of articular cartilage breakdown in osteoarthritis (OA), causes of pain and disability in OA, the pathogenesis and treatment of various forms of amyloidosis, the pathogenesis of dermatomyositis, and immunologic and biochemical markers of cartilage breakdown and repair. http://www.iupui.edu/~solctr/research/details.php?id=296 The NIC anchors a campus effort to investigate the behavior of single molecules and nanostructures, with an emphasis on medical, biological, and materials science applications. The NIC provides IUPUI researchers with state-of-the-art single molecule imaging and nanoscale characterization and manipulation tools, such as wide-field single molecule fluorescence microscopy, near-field optical microscopy, a BioScope AFM (combined atomic force and optical microscopy), magnetic force microscopy, and confocal fluorescence correlation spectroscopy (FCS). http://www.iupui.edu/~solctr/research/details.php?id=297 The mission of the National Center of Excellence in Women\'s Health is to develop a coordinated, unified framework in which to provide state-of-the-art clinical care for women, to teach health care providers and lay people about women\'s health issues, to create new programs to deliver information about preventive medicine to women and their families throughout the State of Indiana, to learn from women how to provide them with better and more user-friendly health care, to develop a research agenda linking basic science with clinical care, and to foster the development of careers of women in academic health centers. http://www.iupui.edu/~solctr/research/details.php?id=298 The National Council on Public History is a not-for-profit professional association devoted to the study and practice of public history. It works to serve the growing community of public historians, to promote the study of public history at the college/university level, and to enhance the public\'s awareness of the value and uses of history in daily life. http://www.iupui.edu/~solctr/research/details.php?id=299 The Institute\'s central mission is to study and develop cutting edge reporting techniques, particularly using computer technology, and to teach these techniques to professional journalists, students, and journalism educators. These techniques include identifying and searching online databases acquiring electronic data from government and other agencies creating personal databases for in-depth reporting projects and selecting appropriate statistical techniques for analysis of data. http://www.iupui.edu/~solctr/research/details.php?id=322 The mission of the NMR Center is to conduct basic and applied research on metabolism and on structure-function relationships of biological macromolecules using the techniques of nuclear magnetic resonance (NMR). To this end, the NMR center maintains and operates a triple resonance, z-axis pulsed field gradient 500 MHz NMR spectrometer for studies on biological macromolecules, and a wide bore double resonance 300 MHz NMR spectrometer for field dependent measurements on biological macromolecules and for metabolic measurments on cells and tissues. In addition, along with providing expertise in and consultations on NMR of biological macromolecules, the NMR center makles available and participates in the development of the latest in free software for assignment and analysis of multidimensional NMR spectra of biological macromolecules. http://www.iupui.edu/~solctr/research/details.php?id=300 The mission of the NMR Center is to conduct basic and applied research on metabolism and on structure-function relationships of biological macromolecules using the techniques of nuclear magnetic resonance (NMR). To this end, the NMR center maintains and operates a triple resonance, z-axis pulsed field gradient 500 MHz NMR spectrometer for studies on biological macromolecules, and a wide bore double resonance 300 MHz NMR spectrometer for field dependent measurements on biological macromolecules and for metabolic measurments on cells and tissues. In addition, along with providing expertise in and consultations on NMR of biological macromolecules, the NMR center makles available and participates in the development of the latest in free software for assignment and analysis of multidimensional NMR spectra of biological macromolecules. http://www.iupui.edu/~solctr/research/details.php?id=342 The Office of Clinical Research supports and promotes clinical research at the Indiana University School of Medicine and its affiliated hospitals. We serve investigators and their staff, research volunteers, and work as a liaison for industries looking to place clinical studies at our institution. Our Mission The primary mission of the Office of Clinical Research at the Indiana University School of Medicine is to promote human health through the performance of the highest quality, ethically conducted, clinical research. This involves engaging in novel clinical research, developing an infrastructure to ensure that investigators have access to a high quality research team, community engagement in clinical research and encouraging intra-institutional collaborations to increase clinical research productivity. http://www.iupui.edu/~solctr/research/details.php?id=301 Long regarded by academic peers and industry as a leading center for preventive dentistry research, the Oral Health Research Institute has served as Indiana University School of Dentistry\'s core research facility for over four decades. http://www.iupui.edu/~solctr/research/details.php?id=302 The Outpatient Clinical Research Facility provides faculty physicians and funding agencies the resources and qualified staff to perform clinical trials that meet high standards of performance. http://www.iupui.edu/~solctr/research/details.php?id=303 This high-performance computing laboratory is primarily a research laboratory in the area of performance enhancement of large and distributed applications. Research focuses on the development of efficient tools for distributed systems and data intensive applications. Projects underway in the laboratory are currently exploring novel techniques for data access and retrieval in large scientific databases such as chemical and biological databases. The laboratory features state-of-the-art Sun workstations. http://www.iupui.edu/~solctr/research/details.php?id=304 Over the years the Peirce Project has accumulated important resources in American philosophy and culture, including nationally significant collections of correspondence and papers by Max Fisch and Charles Morris, a substantial library of American thought, and a vast quantity of material directly relating to the life of Charles S. Peirce. http://www.iupui.edu/~solctr/research/details.php?id=305 The Visualization and Interactive Spaces (VIS) Lab explores the use of computer-generated graphics and novel user interaction techniques to support easy and enjoyable access to digital information. The Lab is especially interested in environments that involve learning in classrooms, labs, and informal settings such as museums and discover centers. http://www.iupui.edu/~solctr/research/details.php?id=306 The Polis Center is an academic research center with a practical and applied orientation that focuses on urban-related issues, primarily in Indianapolis and other Indiana cities. Our goal is to develop knowledge that will serve the common good and invigorate the sense of community in this city and beyond. The Polis Center also specializes in community information systems, advanced spatial technologies, Geographic Information Systems, and related Web services. http://www.iupui.edu/~solctr/research/details.php?id=308 Fosters study, research, and education on critical legal and regulatory issues facing state governments places students in research initiatives, educational programs, and internships within all branches of state government and broadens the dialog between the academic legal community and state governments by promoting and disseminating contemporary scholarship on issues confronting those governments. http://www.iupui.edu/~solctr/research/details.php?id=309 The Protein Analysis and Research Center (PARC), formerly the IUSM Proteomics Core, provides proteomics services and expert consulting to academic investigators, offering technologies such as two-dimensional gel electrophoresis and liquid chromatography mass spectrometry, and developing new methods for protein separation, identification and quantification, and characterization. http://www.iupui.edu/~solctr/research/details.php?id=310 The Protein Expression core laboratory is a service laboratory whose primary goal is to assist investigators at Indiana University in protein structure-function studies. Services offered by the expression core involve guidance in the selection of a recombinant expression system (prokaryotic and eukaryotic), subcloning genes of interest into expression vectors, optimizing protein expression and purification. The core also assists in the generation of site-directed mutants of the proteins of interest and in scaling up of recombinant protein production. The core is equipped to express proteins in E.coli and Sf9 insect cells. Among the equipment in the core are a New Brunswick Bioflow 3000 Fermentor that has the capacity to run 10 Liter fermentation, a Thermo Spectronic French Pressure Cell Press, Pharmacia FPLC and Bio-Rad Biologic LP protein purification systems. http://www.iupui.edu/~solctr/research/details.php?id=311 The Indiana University Public Opinion Laboratory is an interdisciplinary survey research center that provides services to a wide variety of private, nonprofit and governmental organizations. The lab also serves the entire IUPUI campus by conducting research for faculty members, students and various university departments. The majority of the research conducted by the Public Opinion Laboratory is applied work in the fields of public opinion, marketing, health care and customer satisfaction. http://www.iupui.edu/~solctr/research/details.php?id=312 This core provides investigators with quantitative analysis of all physiological amino acids in biological fluids. Acceptable samples include but are not limited to plasma and urine. http://www.iupui.edu/~solctr/research/details.php?id=313 The Tobias Leadership Center will be a preeminent source, collaborator and convener on the subject of effective leadership across multiple sectors in the economy. This concentrated focus on cross-sectored leadership in the corporate, public service, education and nonprofit communities will distinguish the center\'s agenda as unique among leadership programs nationwide. http://www.iupui.edu/~solctr/research/details.php?id=314 Identification of genes, proteins, and interactions that mediate tissue regeneration v. scar formation model systems include amphibians regenerate complex structures such as limbs, jaws, spinal cord, parts of the eye and heart, as well as mammalian systems that regenerate blood, bone, muscle and epithelia. http://www.iupui.edu/~solctr/research/details.php?id=315 Regenstrief Institute, Inc., an internationally-recognized informatics and healthcare research organization, is dedicated to the improvement of the health of the public through research that enhances the quality and cost-effectiveness of health care. The mission of Regenstrief Institute is to conduct research to improve health care by improving the capture, analysis, content, and delivery of the information needed by patients, their health care providers, and policy makers, and to conduct interventional studies designed to measure the effect of innovations on the efficiency and quality of health care. Institute investigators and affiliates conduct health services research, research on health care for the elderly, as well as research and development in informatics. Regenstrief has research fellowship programs in health services research and medical informatics. For more complete information regarding Regenstrief Institute, its research, and its investigators, please visit the web site www.regenstrief.org. http://www.iupui.edu/~solctr/research/details.php?id=341 The Richard G. Lugar Center for Renewable Energy was established to address the societal needs for clean, affordable and renewable energy sources, improve the nation\'s energy security, and reduce global warming. Its primary mission is to promote research excellence in the area of renewable energy through collaborative efforts among faculty in the disciplines of engineering, chemistry, physics, biology, and environmental affairs. It will promote renewable energy applications through teaching, learning, civic engagement, and synergistic partnerships with industry, government labs and local communities. http://www.iupui.edu/~solctr/research/details.php?id=316 The Riley Child Development Center (RCDC), a University Affiliated Program (UAP), serves families and children from infancy through adulthood who present developmental delays, behavior and learning problems, stressful life situations, and chronic handicapping conditions. The RCDC provides service, outreach and technical assistance, research, and interdisciplinary pre-service training. In addition, basic and advanced degree training experience in disciplines including audiology, medicine, nursing, occupational therapy, physical therapy, medical/genetics, psychology, speech/language pathology, pediatric dentistry, pediatric neurology, social work, child psychiatry, special education, health administration, and nutrition are available to professional trainees. The RCDC is part of a national network funded by the Bureau of Maternal and Child Health and Resources Department and the Administration on Developmental Disabilities of the Department of Health and Human Services. Its mission is to support the independence, productivity, and integration into the community of all citizens across the life span with developmental disabilities. http://www.iupui.edu/~solctr/research/details.php?id=317 The RNTAP Core provides services for the preclinical testing of pharmacological compounds to reduce alcohol and drug abuse, including measures of craving and relapse. The core also investigates measurements of behavioral, physiological and biochemical traits of genetically developed models, for the study of human disease, focusing on the rat as the model animal species. http://www.iupui.edu/~solctr/research/details.php?id=318 The volumes of The Works of George Santayana are unmodernized, critical editions of George Santayana\'s published and unpublished writings. The goal of the editors is to produce texts that accurately represent Santayana\'s final intentions regarding his works, and to record all evidence (textual apparatus listing variants and emandations) on which editorial decisions have been based. http://www.iupui.edu/~solctr/research/details.php?id=344 The Center for Regenerative Biology and Medicine has three core missions: (1) basic research on mechanisms of regeneration; (2) graduate training in regenerative biology and medicine; and (3) translation of basic research into clinical therapies through technology transfer. http://www.iupui.edu/~solctr/research/details.php?id=320 The mission of the Stark Neurosciences Research Institute is to advance our knowledge and understanding of the brain and behavior through research and training programs that apply the latest innovations in biomedical discovery with the central goal of informing ongoing and future treatment of neurological and mental disorders through outstanding science. http://www.iupui.edu/~solctr/research/details.php?id=321 This core provides hematopoietic stem cells from various sources for research in hematopoiesis, vascular repair, and neurodegenerative disorders. http://www.iupui.edu/~solctr/research/details.php?id=323 Tissue Procurement and Distribution facilitates the acquisition and handling of human solid tissue for Cancer Center investigators. The facility assures quality control of these tissues, maintains essential integrity of the specimen for clinical care of the donor, and maintains donor confidentiality. The specific purposes of the facility are to: 1) obtain unfixed, remnant human tissue from routine surgical resections and autopsies 2) collect body fluids (eg. blood, serum, urine) prospectively per protocol 3) provide research investigators with access to such tissues through a central facility that provides quality control of these tissues 4) maintain essential integrity of the specimen for clinical care of the donor and 5) maintain donor confidentiality. http://www.iupui.edu/~solctr/research/details.php?id=324 Many environmental agents and therapeutic drugs elicit toxicological responses in humans. Toxicology faculty direct their research toward understanding the cellular and molecular mechanisms by which these natural and synthetic chemicals may induce cancer. http://www.iupui.edu/~solctr/research/details.php?id=325 The Transgenic and Knockout Mouse Core provides services for the production of transgenic mice and the production of knockout mice. The facility also provides advice concerning construction of transgenic and gene targeting constructs, animal breeding, and maintenance of the resulting mouse colonies. http://www.iupui.edu/~solctr/research/details.php?id=335 Mission Statement: Advance the Use of Active Safety Systems to Reduce Vehicle Crashes and Save Lives. TASI is a university/industry consortium, which is also open to governmental and nongovernmental organizations. Industry participants pay a membership fee and are granted prepublication access to data and reports from TASI sponsored research and development projects. An active safety system is one that attempts to avoid an impending crash either by warning the driver, or by actively taking action(s) to prevent a crash. Active safety systems incorporate sensors, knowledge of vehicle dynamics, decision-making logic to anticipate collisions. The most successful active safety system to date is Electronic Stability Control (ESC). Consumer acceptance of active safety systems continues to be slow, however, because of the difficulty of quantifying cost-benefit analyses. TASIs scope encompasses Research and Development into the causes and mechanisms of collisions, the selection of optimal mechanisms for alerting the driver to take evasive action, the potential of standardization of Human Machine Interface (HMI) to increase consumer acceptance, and methods for component-level, system-level, and human-in-the-loop testing and validation. http://www.iupui.edu/~solctr/research/details.php?id=326 The VA HSR&D Center on Implementing Evidence-Based Practice (CIEBP) was designated a national VA HSR&D Center of Excellence in June 2004 through an effective partnership between the Roudebush VAMC in Indianapolis, Veterans Integrated Service Network (VISN) 11, the Regenstrief Institute, Inc., IU School of Medicine and our academic affiliates. The mission of the Center is to advance the science of transforming the health care system, both within and outside the VA health care system. Our vision is to become the leading national research resource for learning about health system transformation. Our strategy is to partner with managers, clinicians, patients and other researchers in interdisciplinary teams to innovate, foster system redesign and drive broad scale adoption of changes to improve care delivery. Within this overall mission and vision, our research priorities are to: 1) Apply models of care that are safe, effective, patient- and relationship-centered, timely, efficient, and equitable; 2) Identify and share effective approaches for organizational change and rapid cycle process improvement; 3) Implement and disseminate systems interventions, considering human, social and organizational factors, to transform care delivery; 4) Implement health information technology into work flow to improve care; and 5) Redesign health care delivery systems. In pursuit of our mission, we have the following goals: 1) Research. Conduct health services and implementation research to transform health care delivery; 2) Disseminate. Identify, evaluate, communicate and disseminate best clinical and management practices for systems redesign to further VHA’s transformation; and 3) BUILD. Develop capacity (human resources, financial resources, and work processes) and achieve excellence in loyalty, worklife and stability for the Center to accelerate change in healthcare organizations and systems. http://www.iupui.edu/~solctr/research/details.php?id=327 Fundamental and application research in the emerging field of multi-sensory information processing, projects include video surveillance and security using sensor networks in counter-terrorism application. http://www.iupui.edu/~solctr/research/details.php?id=328 The major goal of the Walther Oncology Center is to foster cutting-edge basic scientific laboratory research that focuses on the cellular, biochemical and molecular biology of cancer. Close interactions with cancer clinicians are encouraged in order to accelerate the translation of new laboratory findings towards clinical utility. The aims of the Walther Oncology Center are to: 1) understand the regulatory mechanisms involved in the proliferation, differentiation and function of normal cells and the abnormalities in these capacities which are associated with the progressive nature of tumor cell growth 2) accelerate the translation of new basic scientific information to the clinical research area in order to slow disease progression and obtain a better quality of life for patients suffering from cancer and related disorders and 3) develop and disseminate information that will lead, or help lead, to cures for the different cancers. http://www.iupui.edu/~solctr/research/details.php?id=233 The Center for Law and Health was established in 1987 to conduct legal and empirical research on health law issues in Indiana and the nation interpret health law issues for the bar, government, and the health care community and expand the curriculum and teaching of health law at the law school, while providing opportunities for student participation in Center-sponsored research initiatives, educational programs, and health law internships. http://www.iupui.edu/~solctr/research/details.php?id=340 The Center engages in community health development through research, education, and professional service. The focus is on promoting a multi-sectoral approach to improving the health of communities. The current terms of reference include: To collaborate in the identification of research needs relevant to the Healthy Cities Movement; To conduct and collaborate in the planning and execution of quantitative and qualitative research relevant to the Healthy Cities Movement; To collaborate in the development of a global database and issue periodic reports on the Healthy Cities Movement; To provide research training opportunities for fellow visiting scientists and research trainees of the Organization and from countries throughout this and other WHO regions; To organize and host national and international conferences and congresses on issues relevant to the Healthy Cities Movement; To promote information exchange about Healthy Cities programs, research and resources. http://www.iupui.edu/~solctr/research/details.php?id=330 The Zebrafish Morpholino Oligonucleotide Knockdown Core performs morpholino oligonucleotide injection experiments for laboratories to inhibit specific gene functions. Zebrafish provides an exciting model for a growing community of scientists focusing on the study of various biological questions. Zebrafish is unique among vertebrate models due to the advent of large-scale genetic screening for mutants in development and morpholino technology that allows the suppression of any gene during embryonic stages. This core facility will provide members of the university community and the at large scientific community easy access to the zebrafish experimental system. The Zebrafish Morpholino Oligonucleotide Knockdown Core 1) assists in the identification of zebrafish homologs of genes 2) assists in morpholino oligonucleotide and control design 3) performs morpholino and control oligonucleotide injections and 4) performs or assists with analysis of morpholino-induced phenotype.