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Simon
J. Rhodes, Ph.D.
▪ Developmental
physiology
▪
Molecular basis of
pediatric combined pituitary hormone deficiency diseases
▪ Transcriptional
regulation of endocrine organ development
RESEARCH GOALS
We are interested in characterizing
transcription factors in order to better understand their:
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Basic Biology
- Role in development of the pituitary
gland and other organs such as the brain and bone
- Mechanism of transcription
- Target genes
- Partner proteins
- Regulation by modification
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Applications to Human Medicine
- Heritable and sporadic (pituitary)
diseases
- Hormone deficiencies,
especially
combined pituitary hormone deficiency (CPHD)
diseases in children
- Growth diseases
- Reproductive diseases
- Thyroid diseases
- Pituitary tumors
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Applications to Agriculture
- Characterization in animals
of agricultural importance
- Correlation of gene loci with
useful traits
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Role in Regenerative Biology
and Medicine
- Understand regeneration in amphibians
- Apply knowledge to human medicine
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