Electronic Submissions

The IUPUI/Clarian IRBs (IRB-01, IRB-02, Methodist IRB-03, IRB-04, and IRB-05) require that all study documents be submitted electronically to the IRB. Such submissions must be made via email from the links below.

Please note that the principal investigator is not required to send the email message him/herself; rather, another member of the principal investigator’s research staff may submit, provided that the principal investigator is copied on the message. Copying the principal investigator on the message also serves as his/her signature. Refer to Sponsor Letter Regarding the Electronic IRB Submission Process for more information.

Where to Submit

Submissions should be made directly to the IRB of record for your particular study. Please note the expertise of each IRB and submit your research application accordingly. For full-board studies, the principal investigator is responsible for making an initial determination regarding which IRB to submit to; however, RCA staff may transfer the IRB to another IRB if appropriate.

IRB	Specialty
IRB-01	Research in the behavioral and social sciences
IRB-02	Biomedical research in hematology/oncology, nephrology, infectious diseases, pediatrics, neurology, endocrinology, genetics, and general medicine
IRB-03 (Methodist)	Biomedical research conducted solely or primarily at the Methodist Hospital campus or at a Methodist affiliate site (i.e. the majority of subjects will be enrolled at Methodist Hospital or a Methodist affiliate site)
IRB-04	Biomedical research in pediatrics, hematology/oncology, dentistry, cardiology, psychiatry, surgery, OB/GYN, and general medicine
IRB-05	Biomedical research in infectious diseases, pediatrics, ophthalmology, radiology, hematology/oncology, gastroenterology, psychiatry, surgery, endocrinology, and general medicine

New expedited studies (except for studies to be reviewed by IRB-03) should be submitted to irbexp@iupui.edu and will be assigned to an IRB by RCA staff. In addition, exempt submissions, submissions for the NCI CIRB facilitated review process, Applications for Research Not Subject to FDA or Common Rule Definitions of Human Subjects Research, and Applications for Non-Research Student Projects should also be submitted to irbexp@iupui.edu (unless they are to be reviewed by IRB-03).

Once initial review is completed, all subsequent submissions regarding the study should be submitted to the IRB of record for that particular study. If you are unsure of which IRB should receive your submission, please visit the Read-Only Human Subjects Submission Tracking System at http://webdb.iu.edu/iupuirsp/HS_Study_Information.htm.

Research at Methodist Hospital

All biomedical research (including full-board, expedited, and exempt studies) to be conducted solely at Methodist Hospital and/or a Methodist affiliate site, and studies for which the majority of the patients will be enrolled at Methodist Hospital or a Methodist affiliate site, should be submitted to IRB-03 (mhirb@clarian.org).

How to Submit

To submit an item to a particular IRB for review, click on the appropriate link below to generate an email message to the inbox for the IRB to which your study has been assigned. Please use the appropriate subject line as indicated below. In the text of the message, please note what is being submitted and attach the relevant forms and supporting documents. Once the message and appropriate forms and supporting documents are received by the IRB staff, the submission will be processed for review by the full board or via the expedited review process.

For those items which must be submitted per deadline, please note that deadlines will still be followed and whether deadlines have been met will be evaluated by receipt time noted in the inbox.

Please use the following format in the subject line of all emails:
IRB Name -Study Number – PI Name – Type of Submission (and submission number, where applicable)

Examples:
• IRB-01 – 0000-00 – Dr. Jane Doe – Amendment 1
• IRB-02 – 0000-00 – Dr. John Doe – New Study
• IRB-04 – 0000-00 – Dr. Jane Doe – Gen Info 1
• IRB-05 – 0000-00 – Dr. John Doe – Continuing Review

If you have a...	Make submissions to:
Submission to IRB-01	irb01@iupui.edu
Submission to IRB-02	irb02@iupui.edu
Submission to IRB-03 (Methodist)	mhirb@clarian.org
Submission to IRB-04	irb04@iupui.edu
Submission to IRB-05	irb05@iupui.edu
Submission to IBC or BHC	ibcbhc@iupui.edu
New expedited protocol submission Submission for exempt review Submission for NCI CIRB facilitated review Application for Research Not Subject to FDA or Common Rule Definitions of Human Subjects Research Application for Non-Research Student Projects	irbexp@iupui.edu
Question regarding which IRB your study has been assigned to	Visit the Read-Only Human Subjects Submission Tracking System at http://webdb.iu.edu/iupuirsp/HS_Study_Information.htm
General question or a question regarding an item which has not been assigned to a specific IRB	resrisk@iupui.edu
Submission for review via the WIRB facilitated review process	All initial submissions should be made to iuwirb@iupui.edu. Additional items such as amendments, continuing reviews, and general information items should be submitted to directly to WIRB via the online submission process at http://www.wirb.com/onlinesubmissions/. Please see http://www.iupui.edu/~resgrad/spon/wirb.html for detailed instructions.
Request for the Investigator 101 CD and/or Test	resrisk@iupui.edu
If you need access to the Read-Only Human Subjects Submission Tracking System	http://webdb.iu.edu/iupuirsp/HS_Study_Information.htm