SH/EAHP 2007 Workshop - Progress in T-cell and NK cell Malignancies - title graphic

Cases by Session

Cases by Contact Submitter

Submitter Contact Information

 Session 2. Ph- chronic myeloproliferative disease

Session Chair Presented Case
Thiele - Presentation Link
Presented Cases
  • 067:
Chronic Eosinophilic Leukemia associated with FIP1L1/PDGFRa fusion, and highly responsive to low dose imatinib.
  • 069:
Acute bilineal leukemia arising in the background of the 8p11 myeloproliferative syndrome.
  • 081:
Chronic myeloproliferative disorder with t(5;12).
  • 094:
Essential thrombocythemia progressing to acute myeloblastic leukemia with acquisition of a Philadelphia chromosome/BCR-ABL1 fusion as a secondary event.
  • 110:
Chronic myeloproliferative disorder, not otherwise classified, with associated JAK2-V617F mutation.
  • 125:
Descriptive until further follow-up:
Hypercellular bone marrow (60-70%) with panmyeloid hyperplasia and associated with normocytic anemia, thrombocytosis and a minimal JAK2 V617F mutation burden. The features are insufficient to support a diagnosis of a chronic myeloproliferative disorder at this time.
  • 148:
Progressive bone marrow fibrosis, likely immune-mediated (autoimmune myelofibrosis).
  • 219:
Acute myeloid leukemia evolving from previously diagnosed chronic myeloproliferative disease with myelofibrosis.
Other Cases in the Session
  • 018:
 Chronic eosinophilic leukemia (CEL)
  • 028:
 Myelodysplastic/myeloproliferative disease, unclassifiable (WHO).
  • 045:
 Myeloproliferative disorder with eosinophilia/precursor T lymphoblastic lymphoma, lacking a demonstrable 8p11 translocation.
  • 066:
 Chronic myeloproliferative disorder, chronic neutrophilic leukemia.
  • 078:
 Chronic myeloproliferative disorder, most consistent with chronic eosinophilic leukemia.
  • 079:
 Peripheral blood with normocytic anemia, lymphopenia, monopenia, dysplastic micromegakaryocytes and 15% blasts.
- Markedly hypocellular marrow (10-20%) with panhypoplasia, marked myelofibrosis and increased blasts (10%) with features transforming into an accelerated or blast phase.
  • 088:
 Pediatric idiopathic myelofibrosis.
  • 100:
 Acute myeloid leukemia with the t(8;21) arising in a patient with post-polycythemic myelofibrosis and a concurrent extramedullary myeloid sarcoma.
  • 102:
 Due to the prior diagnosis of T-LBL and the chromosomal karyotype, it was concluded that the patient had the 8p11 myeloproliferative syndrome.
  • 105:
 Chronic basophilic leukemia.
  • 106:
 FIP1L1-PDGFRA positive chronic eosinophilic leukemia
(Alternate: systemic mastocytosis with eosinophilia and FIP1L1-PDGFRA fusion).
  • 117:
 PDGFRB-rearranged eosinophilic disorder (atypical MPD).
  • 122:
 Transient leukemia (transient myeloproliferative disorder) of Down syndrome.
  • 127:
 Polycythemia vera containing atypical JAK2 mutations.
  • 133:
 Chronic eosinophilic leukemia vs. MDS/MPD, unclassifiable with eosinophilia.
  • 169:
 Chronic neutrophilic leuekemia with JAK2 V617F mutation.
  • 174:
 Chronic neutrophilic leukemia.
  • 178:
 Polycythemia vera, post-polycythemic (fibrotic) stage.
  • 181:
 Essential thrombocythemia (vs. myeloproliferative/myelodysplastic syndrome, unclassifiable), MPL W515L+ and phospho-STAT5+.
  • 182:
 Chronic Eosinophilic Leukemia with t(8;9)(p23;p24).
  • 196:
 Chronic eosinophilic leukemia with interstitial deletion on chromosome 4q12 resulting in the FIP11L1-PDGFRa fusion.
  • 197:
 Chronic eosinophilic leukemia.
  • 200:
 Chronic neutrophilic leukemia.
  • 203:
 Secondary AML (M5b FAB) as a transformation of an unclassified myeloproliferative syndrome (JAK2 negative).
  • 208:
 Chronic neutrophilia associated with occult plasma cell dyscrasia.

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