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Session 4. Myelodysplastic syndromes
Session Chair Presented Case
Orazi -
Presentation Link
Presented Cases
036
:
Co-existent 5q minus syndrome and B-CLL.
061
:
Myelodysplastic syndrome of RAEBII type? 5q?
075
:
Based on the absence of splenomegaly and leukoerythroblastic blood smear with poikilocytosis, a CMPD is unlikely. Without the establishment of >20% blasts, the diagnosis of AML cannot be substantiated. Also, AML-M7 generally manifests a predominantly megakaryoblastic proliferation with a higher percentage of blasts in the marrow and peripheral blood. The most difficult distinction is between MDS with fibrosis and APMF, which share numerous clinical and morphologic features. The duration of the pancytopenia in this patient cannot reliably be ascertained. However, the cytogenetic findings (-5, -7, +8, plus other complex abnormalities) support the diagnosis of a high-grade MDS with fibrosis.
131
:
Refractory cytopenia with Multilineage dysplasia (RCMD) associated with a paroxysmal nocturnal hemoglobinuria (PNH) clone.
141
:
Myelodysplastic syndrome associated with isolated del (5q) chromosome abnormality ("5q- syndrome").
158
:
Slightly hypercellular bone marrow (40%) with no morphologic or immunohistochemical features of myelodysplasia. Clonal cytogenetic abnormality of uncertain clinical significance.
165
:
Refractory anemia with excess blasts-2 (RAEB-2) (see comment)
Comment: The erythroid series is markedly increased (~60%) and is predominantly immature. Myeloblasts represent approximately 5-7% of total, thus less than 20% of non-erythroid cells.
192
:
Refractory cytopenia with multilineage dysplasia.
Other Cases in the Session
007
:
Myeloma with Refractory Cytopenia and Multilineage Dysplasia.
085
:
Monoclonal gammopathy of unknown significance with 5q- syndrome and anemia of chronic disease.
097
:
Fanconi anemia with evolution to myelodysplastic syndrome.
115
:
Hemophagocytic lymphohistiocytosis and coexisting Myelodysplastic syndrome.
124
:
Refractory Cytopenia with Multilineage Dysplasia associated with pure red cell aplasia.
161
:
Refractory cytopenia with multilineage dysplasia and ringed sideroblasts (~15%).
191
:
High grade myelodysplastic syndrome/?acute panmyelosis with myelofibrosis.
215
:
Bilineal acute leukemia, myeloid and B-lymphocytic, arising from a myelodysplastic syndrome.
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