Submitter(s): Danielle Canioni, Olivier Hermine, Nicole Brousse. Clinical history Woman of 50 years. Cutaneous lesions evoking a mastocytosis associated with a recent splenomegaly. Hyperleucocytosis and anemia. No previous treatment. Details of gross/microscopic pathology: Bone marrow biopsy Fixation in Bouin fixative. Immunophenotype (flow cytometry/immunohistochemistry): The nests of spindle cells were stained with CD117 and tryptase antibodies. Cytogenetics: No cytogenetics for this case. Molecular analysis: No molecular analysis. Interesting feature(s) of submitted case: The association of a myeloproliferative syndrome and a sytemic mastocytosis. Proposed diagnosis: Bone marrow mastocytosis associated with a myeloproliferative syndrome looking like an osteomyelosclerosis. Panel diagnosis: SM-AHNMD/CIMF Comments: Studies performed by the panel: no amplification for c-kit, probably WT JAK-2 Images: Back to Top Back to Cases by Session Back to Cases by Contact Submitter |