• Professor of Microbiology and Immunology
  
  
• Campus Address: MS 420 D
• Telephone: (317) 274-2270
• E-mail: rschloe@iupui.edu
  

Hal Broxmeyer named distinguished professor at IUSM (click here for more details)

Janice Blum discusses Immunology & Infectious Diseases (click here for more details)

Training:
• B.S., 1968, Boston College
• M.S., 1972, University of Virginia
• Ph.D., 1973, University of Virginia
• Postdoctoral Fellow, 1973-1975, University of Virginia

Description and summary of research focus of the laboratory:
Research interest of Dr. Schloemer's laboratory centers on hepatitis viruses, liver diseases, and heptocellular carcinoma. After demonstrating (i) inhibition of synthesis of b -interferon by the hepatitis B virus (HBV) core antigen, (ii) the transacting function of the HBV X antigen, which is now implicated in the development of hepatocellular carcinoma, and (iii) the regulation of expression of the enhancer/promoters of several HBV genes, the focus of research has now shifted to devising cures for HBV infections, especially chronic infections. This shift of focus has led to a joint project with Dr. Srivastava on the development of liver-specific AAV vectors which would employ HBV components. The near-term aim is to use these new liver-specific vectors to deliver antiviral agents to interfere with the replication of HBV, and with the development of hepatocellular carcinoma.

Publications
Twu, J.-S., and R.H. Schloemer. 1987. "Transcriptional transactivation function of Hepatitis B virus." J. Virol. 61:3448-3453.

Twu, J.-S., C.-H. Lee, P.M. Lin and R.H. Schloemer. 1988. "Suppression of human beta-interferon by Hepatitis B virus." Proc. Natl. Acad. Sci. 85:252-257.

Whitten, T.M., A.T. Quets, and R.H. Schloemer. 1991. Identification of the hepatitis B virus factor that inhibits the expression of the b -interferon gene. J. Virol. 65:4699-4704.

Gerlach, K.K. and R.H. Schloemer. 1992. Hepatitis B virus C gene promoter is under negative regulation. Virology. 189:59-66.

Goebel, W.S., M.R. Bochan, R.H. Schloemer, and Z. Brahmi. 1996. Characterization of perforin gene expression in human cytolytic cell lines exposed to sensitive target cells. Molecular Immunology 33:341-349.

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