• Professor of Microbiology and Immunology
• Professor of Surgery
  
• Campus Address: UH 4258
• Telephone: (317) 274-4370
• E-mail: mpescov@iupui.edu

Hal Broxmeyer named distinguished professor at IUSM (click here for more details)

Janice Blum discusses Immunology & Infectious Diseases (click here for more details)

Training:
• BM.Sc., 1977, Northwestern University Evanston, Illinois, Honors Program
  in Medical Education
• M.D., 1979, Northwestern University Medical School Chicago, Illinois
• Post Doctoral, 1979-1981;Medical Staff Fellow, NCI, 1981-1985; General
  Surgery Residency, 1985-1987; University of Minnesota, Minneapolis
  Minnesota
• Transplantation Fellow and Gastrointestinal Endoscopy Fellow,1987-1988,
  University of Minnesota, Minneapolis, Minnesota; NIH Bethesda Maryland

Description and summary of research focus of the laboratory:
Dr. Pescovitz's laboratory in interested in porcine cellular immunology with particular focus on aspects that are unique to the pig. The pig is the most likely candidate for a xenogeneic organ donor to humans. An understanding of the pig immune system will be important in understanding and controlling the interactions between the pig donor and the human host. The main target of his studies is an unusual T-cell subset present in large numbers in the peripheral blood of adult animals that expresses both the CD4 and CD8 markers. Within the past year his group has generated a panel of reagent against CD3, CD40 and CD40L (CD154) and is currently using these reagents to look at the function of the CD4 and CD8 protiens in this population. The laboratory is also involved in pancreatic islet cell research and clinical transplantation. Lastly the laboratory provides laboratory support for multiple clinical transplant research trials including those using anti-CD25 to treat new onset diabetics and anti-CD20 to reduce alloimmunization in patients awaiting renal transplantation.

Publications
Owens, C.D., Book, B.K., Sidner R.A., Fineberg, N.A., Filo, R.S., Pescovitz, M.D. Deletion of T-cell Vb families following human renal transplantation. Transplantation Proc 29: 1141-1142, 1997.

Gane, E., Saliba, F., Garcia, J.C., O'Grady, J., Pescovitz, M.D., Lyman, S., Robinson, C.A. Randomised trial of efficacy and safety of oral ganciclovir in the prevention of cytomegalovirus disease in liver-transplant recipients. Lancet 350: 1729-1733, 1997.

Dalla Vecchia, L. K., Book, B.K., Milgrom, M.L., Jindal, R.M., Leapman, S.B., Filo, R.S., Pescovitz, M.D. Predictive value of enzyme-linked immunosorbent assay-detected IgG anti-HLA antibodies for pediatric renal allograft rejection. Transplantation 64:1744-1747, 1997.

Pescovitz, M.D., Book, B.K., Aasted, B., Dominguez, J., Ezquerra, A., Trebichavsky, I. Novikov, B., Valpotic, I., Nielsen, J., Arn, S., Sachs, D.H., Lunney, J.K., Boyd, P.C., Walker, J., Lee, R., Lackovic, G., Kirkham, P., Parkhouse, R.M.E., Saalmüller, A. Analyses of monoclonal antibodies reacting with porcine CD3: Results from the Second International Swine CD Workshop. Vet Immunol Immunopathol, 60:261-268. 1998.

Interleukin-2-receptor blockade with daclizumab to prevent acute renal rejection in renal transplantation. Vincenti, F., Kirkman, R., Light, S., Bumgardner, G., Pescovitz, M., Halloran, P., Neylan, J., Wilkinson, A., Ekberg, H., Gaston, R., Backman, L., and Burdick, J., for the Daclizumab Triple Therapy Study Group. N Engl J Med 338:161-165. 1998.

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