• Assistant Research Professor
• Assistant Member of the Walther Oncology Center

• Campus Address: 312 R2
• Telephone: (317) 274-7553
• E-mail: yjkim@iupui.edu

Hal Broxmeyer named distinguished professor at IUSM (click here for more details)

Janice Blum discusses Immunology & Infectious Diseases (click here for more details)

Training:
• B.S., 1972 Seoul National University, Seoul, Korea
• M.S., 1977 Seoul National University, Seoul, Korea
• M.S., 1980 University of North Carolina, Chapel Hill, North Carolina
• Ph.D..1985 University of Georgia, Athens, Georgia

Description and summary of research focus of the laboratory:
TGF- b 1 is an immune suppressive cytokine and inhibits effector differentiation of cytotoxic T lymphocyte (CTL), facilitating tumors to evade anti-tumor immune responses. My research is focused on investigation of how 4-1BB (CD137) and CD30, costimulatory molecules as members of TNF receptor family, interact with TGF- b 1 signaling to regulate CTL cytotoxic activity against tumor cells.

Publications
Li, G., Kim, Y.-J., Mantel, C. R., and Broxmeyer, H.E. P-selectin enhances generation of CD14 + CD16 + dendritic-like cells and inhibits macrophage maturation from human peripheral blood monocytes.    J. Immunol. 171: 669-677, 2003.

Ogawa, K., Chen F., Kim Y.-J., and Chen, Y. Transcriptional regulation of Tristetraproline by transforming factor-b in human T cells. J. Biol. Chem. 278: 30373-30381, 2003.

Mantel, C.R, Gelfanov, V.M, Kim, Y.-J, McDaniel, A, Lee Younghee, Boswell H.S, and Broxmeyer, H.E.   P21 waf-1 -Chk1 pathway monitors G1-phase microtubule integrity and is crucial for restriction point transition. Cell Cycle 1:327-336, 2002.

Kim, Y.-J., Li, G., and Broxmeyer, H. E.   4-1BB ligand stimulation enhances myeloid dendritic cell maturation from human umbilical cord blood CD34 + progenitor cells. J. Hem. & Stem Cell Res . 11:895-903, 2002.

Kim, Y-J., Brutkiewicz, R.R., and Broxmeyer, H.E.   Role of 4-1BB (CD137) in the functional activation of cord blood CD28-negative CD8 + T cells.   Blood   100:3253-3260, 2002.

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