• Assistant Professor of Microbiology & Immunology
• Assistant Member of the Walther Oncology Center

• Campus Address: R2 378
• Telephone: (317) 274-7560
• E-mail: schong@iupui.edu

Hal Broxmeyer named distinguished professor at IUSM (click here for more details)

Janice Blum discusses Immunology & Infectious Diseases (click here for more details)

Training:
• B.S. 1976; Biology, Seoul National University, Seoul, Korea
• M.S. 1978; Biology, Seoul National University, Seoul, Korea
• Ph.D. 1987; Biology, University of Virginia, Charlottesville, VA
• Postdoctoral 1987-1989; University of Virginia, Charlottesville, VA, Mentor;
  Dr. Victor Engelhard.
•1989-1993; Section of Immunobiology, Yale School of Medicine, Mentor;
  Dr. Charles Janeway, Jr.

Description and summary of research focus of the laboratory:
My lab studies the host innate immune response mediated by Toll Like Receptor (TLR). In particular, we perform research on how microbes escape host innate immune responses by modulating the TLR mediate immune responses.

Dr. Hong's laboratory is particularly interested in understanding the function of the family of Toll-like receptors (TLR) that plays an essential role in innate immune recognition of pathogen associated molecular pattern. His laboratory is particularly interested in characterizing signal(s) mediated by an individual TLR. As one of the model system, they are trying to analyze the role of a signaling molecule called pellino that is involved TLR mediated signal.

Dr. Hong's laboratory laboratory is also interested in understanding the immune modulation mediated by microbial organism. As a model system, they try to understand how vaccinia virus escapes innate immune response mediated by TLR.  

Publications
Soon-Cheol Hong, 2004.  "Interaction of Innate and adaptive immune responses. Toll Receptors - Potential Link of infection to rejection. In "Immunobiology of organ transplantation" D. Wilkes and W. Burlingham, editors.  Kluwer/Plenum Press, New York.

Seon-Ju Yeo, Jae-Geun Yoon, Soon-Cheol Hong , and Ae-Kyung Yi. 2003.   CpG DNA induces self- and cross-hyporesponsiveness of RAW264.7 cells in response to CpG DNA and LPS. The Journal of Immunology , 170-1052-1061.

Ae-Kyung Yi, Jae-Geun Yoon, Seon-Ju Yeo, Soon-Cheol Hong , B. Keith English, and Arthur M. Krieg.   2002.   Role of Mitogen-Activated Protein Kinases in CpG DNA-Mediated IL-10 and IL-12 Production: Central Role of MEK/ERK in the Negative Feedback Loop of the CpG DNA-Mediated Th1 Response. The Journal of Immunology, 168: 4711-4720 .

Tania S. Gourley, Dipak R. Patel, Kevin, Nickerson, Soon-Cheol Hong, and Cheong-Hee Chang. 2002. Aberrant expression of Fas ligand in mice deficient for the MHC class II transactivator (CIITA). The Journal of Immunology , 168: 4414-4419 .

Ae-Kyung Yi, Jae-Geun Yoon, Soon-Cheol Hong, Thomas W. Redford, and Arthur M. Krieg. 2001. LPS and CpG DNA synergize for TNF- a production through activation of NF- k B. International Immunology. 13:1391-1404.

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