Training:
• B.S., 1983: Sichuan University, Chengdu, China
• M.S., 1989: Beijing Agricultural University, Beijing, China
• M.S., 1992: New York University
• Ph.D., 1994: New York University
• Post doctoral, 1994-1995: Aaron Diamond AIDS Research Center,
Rockefeller University
• Post doctoral, 1995-1997: Dana Farber Cancer Institute,
Harvard Medical School Summary of the focus of the research of Dr. He:
Dr. Johnny He's laboratory research mainly focuses on the molecular biology of virus-host interactions. This includes molecular mechanisms of HIV-1 neuropathogenesis, regulation of HIV and HCV replication by host factors, and the role of HIV-1 Tat-interacting protein Tip110 in eukaryotic control of gene transcription and pre-mRNA processing. Description and summary of research focus of the laboratory:
My laboratory research focuses on the molecular biology of host-virus interactions. Viral pathogenesis is complex and multifactorial involving numerous components from both the virus and the host. It is my long-term goal to understand molecular mechanisms of host-virus interaction, with emphases on how the viruses such as human immunodeficiency virus (HIV) and human hepatitis C virus (HCV) make use of the cellular machinery of the host to the virus's advantages and the host's disadvantages. It is my conviction that answers to these fundamental questions would readily be translated to development of effective therapeutic strategies for diseases caused by these viruses. The major areas of my current research are: (1) Molecular mechanisms of HIV-1 infection and pathogenesis in the central nervous system. This area includes understanding the entry pathway of HIV-1 virus into CD4-negative astrocytes, the mechanisms of non-productive HIV-1 replication in astrocytes, and the mechanisms of neuronal cell death induced by HIV-1 infection of microglia and astrocytes. (2) Regulation of HIV and HCV replication by host factors. This area includes the requirement of host factors for various steps of HIV-1 and HCV replication from entry to assembly and virus budding. For HCV, our main goal is to develop an in vitro genetic system suitable for studies on HCV basic virology as well as for anti-HCV drug discovery. In addition, we are also interested in eukaryotic control of gene transcription and pre-mRNA splicing by HIV-1 Tat-interacting protein Tip110. Publications
Liu, Y., Jones, M., Huntington, C.E., Bu, G., Laribee, N., Moir, R., Tanzi, R., Nath, A., and He, J. (2000) Uptake of HIV-1 Tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands. Nature Medicine 6:1380-1387. Liu, Y., Li, J., Kim B.O., Pace B.S., and He, J. (2002) HIV-1 Tat protein-mediated transactivation of the HIV-1 LTR promoter is potentiated by a novel nuclear Tat-interacting protein of 110 kDa, Tip110. Journal of Biological Chemistry 277:23854-23863. Liu, Y., Liu, H., Kim, B. O., Nath, A., Li, J., Blum, J., and He, J. (2004) CD4-independent infection of astrocytes by human immunodeficiency virus type 1 (HIV-1): Requirement for the human mannose receptor . Journal of Virology 78:4121-4133. Kim, B. O., Liu, Y., Zhou, B., and He, J. (2004) Induction of C chemokine XCL1 (lymphotactin/SCM-1 a /ATAC) expression by human immunodeficiency virus type 1 (HIV-1) Tat protein . Journal of Immunology 172:1888-1895. Liu, Y., Kim, B. O., Kao, C-H., Jung C-Y., Dalton J. T., and He, J. (2004) Tip110, a potent repressor of androgen-dependent androgen receptor-mediated gene transactivation. Journal of Biological Chemistry 279:21766-73. Search Pub Med Return to Homepage |
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