• Professor of Medicine, Infectious Disease
• Professor of Microbiology & Immunology

• Campus Address: EH 435
• Telephone: (317) 274-8114
• E-mail: bbatteig@iupui.edu

Hal Broxmeyer named distinguished professor at IUSM (click here for more details)

Janice Blum discusses Immunology & Infectious Diseases (click here for more details)

Description and summary of research focus of the laboratory:
Our laboratory is currently funded to examine the fine specificity of the human humoral immunity to Chlamydia trachomatis genital infections. Using murine monoclonal antibodies, we have found that the major outer membrane proteins (MOMPs) of genital serovars contain at least 3 serovar-specific epitopes capable of eliciting neutralizing antibody. These epitopes are located in 3 surface exposed variable amino acid regions on the MOMPs. We are now defining the analogous human B cell epitopes using comprehensive sets of overlapping synthetic peptides representing these variable sequence regions.

We plan to evaluate responses to human epitopes in the context of human genital disease to identify B cell epitopes correlated with reduced risk of acquisition of infection. Such epitopes will be considered vaccine candidates. IN the next funding period, candidate B cell epitopes in combination with consensus human T cell epitopes will be used to design peptide-based experimental vaccines. These experimental vaccines will be tested for immunogenicity and efficacy in primate models of chlamydial genital infection. We also will evaluate the epitope-specific humoral response in primates receiving DNA-based experimental vaccines to determine measurable antibody correlates of protection.

Publications
Batteiger, B.E. 1996 The major outer membrane protein of a single Chlamydia trachomatis serovar can possess more than one serovar-specific epitope. Infect Immun. 64:542-547.

Batteiger, B.E. 1996. Species-, serogroup-, and serovar-specific epitopes are juxtaposed in variable sequence region 4 of the major outer membrane protein of some Chlamydia trachomatis serovars. Infect. Immun. 64:2839-2841.

Arno, J.N., Katz, B.P., VanDerPol, B., Caine, V.A., Batteiger, B.E., Jones, R.B. 1996. Lymphocyte proliferation in response to elementary bodies is not serovar-specific in individuals infected with Chlamydia trachomatis. Immunol. Infect. Dis. 6:1-5.

Srinivas, N., Knupp, C., Batteiger, B.E., Smith, R.A., and Barbhiya, R. 1996. A pharmacokinetic study of didanosine coadministered with or without trimethoprim and/or sulfamethoxazole in HIV seropositive patients. Brit. J. Clin. Pharmacol. 41:207-215.

Search Pub Med

Return to Homepage