Developmental and Molecular Neurobiology (D888/V314)
Instructors: Wei-Hua Lee M.D., Ph.D. (director)
Simon Conway, Ph.D.
Xiaoxi Qiao, Ph.D., M.D.
Eri Hashino, Ph.D.
Kathy Bethin, M.D. Ph.D.
Yansheng Du Ph.D.
Amiee Mayeda, M.D.
James Marrs, Ph.D.
Office: RI 2664 (Lee)
Phone: 274-7116
e-mail: whlee@iupui.edu
Lecture: Tuesday/Thursday 2 –3:30 PM
Location: Daly Center Room 185
Course Description: This is an in-depth course in neurobiology designed to help students understand the molecular and cellular mechanisms that underlie the development, normal and abnormal functions of the nervous system. Special emphasis will be placed on both experimental and theoretical approaches that led to our current knowledge of the nervous system.
Course Goal: To gain an understanding of the molecular and cellular mechanisms that underlie the development, normal and abnormal states of the nervous system. Students will be expected to:
Appreciate classical experiments that led to the current understanding of developmental neurobiology
Grasp the principles of molecular neurobiology, including signal transduction and electrophysiology.
Apply the knowledge learned throughout the course to design experiments in developmental and molecular neurobiology
Required Reading:
Development of the Nervous System. Eds. Dan Sanes, Thomas Reh, and William Harris.
Principals of Neuroscience Eds Eric Kandel, James Schwartz Thomas Jessell
Additional reading assignments will be selected from this text as well as from relevant articles published in top biomedical journals.
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Daly Center Room 185, Tuesday & Thursday 2-3:30 pm |
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Lecture and Exam Schedule |
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Reading Assignment |
LECTURER |
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WEEK 1 |
INTRODUCTION |
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13-Jan |
1 |
Origin of the Nervous System |
Chapter 1 |
Conway |
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WEEK 2 |
Early Embryogenesis |
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18-Jan |
2 |
Polarity and Regionalization |
Chapter 2 |
Conway |
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20-Jan |
3 |
Neurogenesis and Migration |
Chapter 3 |
Lee |
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WEEK 3 |
Determination and Differentiation |
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25-Jan |
4 |
Determination |
Chapter 4 |
Lee |
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27-Jan |
5 |
Differentiation |
Chapter 4 |
Lee |
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WEEK 4 |
Axon Growth and Guidance |
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1-Feb |
7 |
Axon Growth and Guidance |
Chapter 5 |
Lee |
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3-Feb |
8 |
Axon Growth and Guidance |
Chapter 5 |
Lee |
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WEEK 5 |
Axon Targeting |
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8-Feb |
9 |
Axon Targeting |
Chapter 6 |
Lee |
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10-Feb |
10 |
Neural Crest Cells and Axonal Specificity |
Literature articles |
Conway |
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WEEK 6 |
and Exam 1 |
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15-Feb |
11 |
Neurotrophic Facotors |
Literature articles |
Qiao |
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17-Feb |
12 |
Exam 1 |
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WEEK 7 |
Synaptogenesis |
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22-Feb |
13 |
Synaptogenesis |
Chapter 8 |
Lee |
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24-Feb |
14 |
Synaptogenesis |
Chapter 8 |
Lee |
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WEEK 8 |
Construction of synaptic circuitry |
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1-Mar |
15 |
Synaptic Transmission |
Literature articles |
Oxford |
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3-Mar |
16 |
Construction of Synaptic Circuit |
Chapter 9 |
Lee |
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WEEK 9 |
Sensory and Visual System |
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8-Mar |
17 |
The Development of the Sensory Systems |
Literature articles |
Hashino |
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10-Mar |
18 |
The Development of the Visual System |
Literature articles |
Qiao |
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WEEK 10 |
Spring Break |
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WEEK 11 |
Visual and Auditory Systems |
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22-Mar |
21 |
The Development of the Auditory System |
Literature articles |
Hashino |
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24-Mar |
22 |
Experimental Approaches |
Literature articles |
Marrs |
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WEEK 12 |
Exam 2 |
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29-Mar |
23 |
Review |
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31-Mar |
24 |
Exam 2 |
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WEEK 13 |
Neuroendocrine and Biorhythm |
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5-Apr |
25 |
The Development of Neuroendocrine System |
Literature articles |
Bethin |
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7-Apr |
26 |
Biorhythm |
Literature articles |
Mayeda |
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WEEK 14 |
Aging |
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12-Apr |
27 |
Behavior Development |
Literature articles |
TBA |
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14-Apr |
28 |
Aging |
Literature articles |
Invited Speaker |
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WEEK 15 |
Neurodegeneration |
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19-Apr |
29 |
Neurodegenerative Diseases |
Literature articles |
Du |
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21-Apr |
30 |
Neurostem Cells |
Literature articles |
Invited Speaker |
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FINALS WEEK |
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25-Apr |
Review |
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1-May |
Final Exam |
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Week 1-16 |
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