My main interest is in Alzheimer’s disease (AD). My research is centered on the amyloid beta precursor protein (APP), from which is derived the amyloid beta fragment that is the main constituent in senile plaques found in the Alzheimer’s brain. Regulation of the APP gene and post-translational processing of this protein are major targets for potential AD treatments. I focus on the effects of potential therapeutic agents on APP production and processing. Currently, I am developing a cell culture model of differentiated human neuroblastoma cells that mimics adult central cholinergic neurons in order to study the interaction of APP with the cholinergic system and to evaluate the effects of potential AD treatments on cholinergic cells.

       Jason Bailey