Office: 317-274-9747
Fax:
Email: jschild@iupui.edu
Professional web site: http://www.engr.iupui.edu/~jhs
Dr. Schild received the B.S. (1983) and M.S. (1988)
degrees in Biomedical Engineering from Case Western Reserve University
and a Ph.D. (1994) in Electrical and Computer Engineering from Rice University
where he was a Shell Foundation Predoctoral Fellow. While at CWRU Dr. Schild
worked as a design engineer in the Implantable Systems Group of the Rehabilitation
Engineering Center. From 1988-91 he worked as a Biomedical Engineer in
a clinical research facility studying residual motor and sensory function
in individuals with traumatic nervous system disorders such as spinal cord
and head injuries, stroke and multiple sclerosis. From 1994-96 he was a
postdoctoral fellow in the Dept. of Physiology & Biophysics, Baylor
College of Medicine. Dr. Schild received an Individual National Research
Service Award from the National Institutes of Health to further his training
in experimental electrophysiology at Oregon Health Sciences University.
Presently, Dr. Schild is with the Department of Electrical Engineering
in the Purdue School of Engineering and Technology where he is an active
member of the IUPUI Biomedical Engineering Program.
Dr. Schild's lab is studying the sensory mechanisms
that regulate the heart and the circulation. An essential aspect of this
research is a biophysical and analytical appreciation for how sensory neurons
and synaptically coupled neural circuits both encode and "process" cardiovascular
information such as blood pressure and heart rate. Experimental techniques
range rom the reductive such as patch-clamp recordings using enzymatically
dispersed sensory neurons and synaptically coupled neurons in thin slices
of brainstem tissue to the integrative such as whole animal baroreceptor
reflex recordings. In addition, computational techniques such as neuronal
modeling and nonlinear systems analysis are used to provide a conceptual
framework with which to interpret experimental observations and organize
future studies. Students from the life sciences and Biomedical Engineering
have opportunities to apply experimental and computational methodologies
to study the sensory mechanisms underlying neurocirculatory control. Dr.
Schild's current support includes a Scientist Development Grant from the
American Heart Association.
Publications:
1. J.H. Schild and D.L. Kunze (1997) An Experimental and Modeling Study of Na+ Current Heterogeneity in Rat Nodose Neurons and Its Impact on Neuronal Discharge. Journal of Neurophysiology, Vol. 78, 3198-3209, 1997
2. J.H. Schild, J.W. Clark, C.C. Canavier, D.L. Kunze and M.C. Andresen (1995) Afferent Synaptic Drive of Rat Medial Nucleus Tractus Solitarius Neurons: Dynamic Simulation of Graded Vesicular Mobilization, Release and non-NMDA Receptor Kinetics. Journal of Neurophysiology, 74(4):1529-1547.
3. J.H. Schild, J.W. Clark, H. Hay, D. Mendelowitz, M.C. Andresen and D.L. Kunze (1995) A- and C-type Rat Nodose Sensory Neurons: Model Interpretations of Dynamic Discharge Characteristics. Journal of Neurophysiology, 72:2338-2358.
4. J.H. Schild, S. Khushalani, J.W. Clark, D.L. Kunze, M.C. Andresen and M. Yang (1993) An Ionic Current Model for Neurons in the Rat Medial Nucleus Tractus Solitarius Receiving Sensory Afferent Input. Journal of Physiology, 469:341-363.