Office: (317)274-7397
Fax: (317)274-1365
Email: jhingtge@iupui.edu
Dr. Hingtgen is involved in developing and studying animal models of depression with special emphasis on the role of serotonin and stress in the etiology and treatment of depression. Early models of depression utilized drug or precursor induced depressive states. Current models being studied are stress induced and use as subjects recombinant inbred lines of mice with the goal of identifying genetic substrates of vulnerability to depression.
Recent Publications:
E.A. Engleman, J.M. Murphy, F.C. Zhou, M. H. Aprison and J.N. Hingtgen. Operant response suppression induced with systemic administration of 5-HTP is centrally mediated. Pharmacology, Biochemistry and Behavior, 52, 525-529, 1995.
B.J. Tarricone, J.N. Hingtgen, J. Belknap, S. Mitchell and J.I. Nurnberger, Jr. Quantitative trait loci associated with the behavioral response of BxD and CxB recombinant inbred mice to restraint stress. Behavior Genetics, 25, 489-495, 1995.