Tatiana Foroud, Ph.D.
Professor
Office:
(317) 278-1291
Email:
tforoud@iupui.edu
My research is primarily in the
area of mapping genes contributing to the susceptibility for common, complex
genetic disorders. These include disorders such as Parkinson’s disease,
Alzheimer’s disease, bipolar disorder and alcoholism. These studies often
include the recruitment of families afflicted with these disorders followed by
molecular genetic studies to detect linkage to particular chromosomal regions.
My group is involved with the statistical genetic analysis of molecular data.
These analyses include both linkage and linkage disequilibrium methods. The goal
is to identify allelic variants which predispose as well as protect individuals
from these disorders.
Publications:
Dick DM, Foroud T, Flury L, Bowman ES, Miller MJ, Rau NL, Moe
PR, Samavedy N, El-Mallakh R, Manji H, Glitz DA, Meyer E, Smiley C, Hahn R,
Widmark C, McKinney R, Sutton L, Ballas C, Grice D, Berrettini W, Byerley W,
Coryell W, DePaulo R, MacKinnon DF, Gershon ES, Kelsoe JR, McMahon FJ, McInnis
M, Murphy DL, Reich T, Scheftner W, Nurnberger JI. Genomewide linkage analyses
of bipolar disorder: A new sample of 250 pedigrees from the National Institute
of Mental Health Genetics Initiative. American Journal of Human Genetics 73(1):107-114,
2003 Jul.
Waguespack SG, Koller DL, White KE, Fishburn T, Carn G, Buckwalter KA, Johnson
M, Kocisko M, Evans WE, Foroud T, Econs MJ. Chloride Channel
7 (CICN7) Gene Mutations and Autosomal Dominant Osteopetrosis, Type II. Journal
of Bone and Mineral Research 18:1513–1518, 2003 Aug.
Willour VL, Zandi PP, Huo Y, Diggs TL, Chellis JL, MacKinnon DF, Simpson SG,
McMahon FJ, Potash JB, Gershon ES, Reich T, Foroud T, Nurnberger
Jr JI, DePaulo Jr JR, McInnis MG. Genome scan of the Fifty-Six Bipolar Pedigrees
from the NIMH Genetics Initiative Replication Sample: Chromosomes 4, 7, 9, 18,
19, 20, and 21. American Journal of Medical Genetics (Neuropsychiatric Genetics)
121B(1):21-27, 2003 Aug.
Foroud T, Ritchotte A, Spence J, Liu L, Lumeng L, Li T-K, and
Carr LG. Confirmation of alcohol preference QTLs in the replicate high alcohol
drinking and low alcohol drinking rat lines. Psychiatric Genetics 13(3):155-161,
2003 Sep.
O’Donnell BF, Wilt MA, Hake A, Stout JC, Kirkwood SC, Foroud T.
Visual function in Huntington’s disease patients and presymptomatic gene carriers.
Movement Disorders 18(9):1027-1034, 2003 Sep.
Pankratz N, Nichols WC, Uniacke SK, Halter C, Murrell J, Rudolph A, Shults CW,
Conneally PM, Foroud T, Parkinson Study Group. Genome-wide
linkage analysis and evidence of gene-by-gene interactions in a sample of 362
multiplex Parkinson disease families. Human Molecular Genetics 12(20):2599-2608,
2003 Oct.