Office: 317-274-0591
Email: echernof@iupui.edu
Professional web site: http://www.biology.iupui.edu/faculty/echernoff.html
 

    Understanding the successful spinal cord regeneration that occurs in amphibians complements other approaches to spinal cord injury. Our laboratory studies the molecular biology of frog tadpole spinal cord regeneration using Xenopus laevis, the Clawed Frog. Projects include characterizing the stem cell properties of frog spinal cord and expression of dorsoventral patterning genes in regeneration. Tadpoles lose their ability to regenerate as they approach metamorphosis, and we compare regenerating and non-regenerable cord. Salamanders regenerate even as adults. We study regeneration in the Axolotl, or Mexican salamander (Ambystoma mexicanum) to determine the contributions that injury-reactive ependymal cells make to the tissue remodeling process and axonal regrowth. We have identified stem cell properties that are common to amphibian limb regeneration as well as spinal cord.
My Center for Regenerative Biology and Medicine page is:  http://www.regen.iupui.edu/oldsite/amphibianhome.html

Publications:

Chernoff,E.A.G., Clarke, D.O.,Wallace-Evers, J.L.,Hungate-Muegge, L.P. Smith, R.C. (2001) The Effects of Collagen Synthesis Inhibitory Drugs on Somitogenesis and Myogenin Expression In Cultured Chick and Mouse Embryos. Tissue and Cell, 33: 97-110

Chernoff EAG, Sato K, Corn A and Karcavich RE (2002) Spinal Cord Regeneration: Intrinsic Properties and Emerging Mechanisms. Sem Cell Develop Biol 13:361-368

Nye HL, Cameron J, Chernoff EAG and Stocum DL. (2003) Regeneration of the Urodele Limb: A Review. Develop. Dyn. 226:280-294.

Chernoff EAG, Stocum DL, Nye HLD and Cameron JA (2003) Urodele Spinal Cord Regeneration and Related Processes. Devel Dyn 226:295-307.

Nye HLD, Cameron, J., Chernoff EAG and Stocum DL (2003) Extending the Table of Stages of Normal Development of the Axolotl: Limb Development. Devel Dyn 226:555-560

Sato K, Corn A, Karcavich R, Smith RC, Chernoff EAG. (2003) Neural stem cell properties and Xenopus spinal cord regeneration. Develop Biol 259:533-534. Society for Developmental Biology and International Society of Developmental Biologists Meeting. Boston, July 30-August 3, 2003.

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