Sean D. Mooney, PhD
Assistant Professor of Medical and Molecular Genetics

E-mail: sdmooney@iupui.edu

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INTRODUCTION
• Mission Statement
• Letter from chairman

FACULTY

EDUCATION
• Graduate Programs
• Postdoctoral Training
• Residency Program
• Other Training

FACILITIES
• Cytogenetics labs
• Basic Research labs
• Molecular Diagnostics labs
• NGVL
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DIVISIONS
• Clinical Genetics
• Cytogenetics
• Hereditary Genomics
• Molecular Genetics & Gene Therapy

SEMINARS
• Department Seminars
• Genetics Research Club

INFORMATION
• Administration
• Location
• Job opportunities

Dr Mooney's research focuses on understanding the molecular basis of human disease, with current efforts working to understand the effects of genomic variation on the proteome. He and his lab apply bioinformatics and structural modeling methods in a collaborative environment, using primarily computational chemistry and sequence based bioinformatics tools.

PUBLICATIONS
Mooney, SD; and Klein, TE (2002) “The Functional Importance of Disease-associated Mutation” BMC Bioinformatics 3:24

Mooney, SD; and Klein, TE (2002) “Structural Models of Osteogenesis Imperfecta Associated Mutations in the COLIA1 Gene” Molecular and Cellular Proteomics 1(11):868-875

Mooney, SD; Klein, TE; Altman, RB; Trifiro, MA; and Gottlieb, B (2003) “A Functional Analysis of Disease-associated Mutations in the Androgen Receptor Gene” Nucleic Acids Research, 31: e42

Mooney, SD and Altman RB (2003) “MutDB: A platform for annotating mutations with functionally relevant data” Bioinformatics, 19: 1858-1860
Hewett, R; Leuchner J; Mooney, SD; and Klein, TE; (2003) “Analysis of mutations in COLIA1 gene with second-ordered rule induction” International Journal of Pattern Recognition and Artificial Intelligence, 17(5): 721-740.

Knudsen, GM; Nishida, CR; Mooney, SD; and Ortiz de Montellano, PR; (2003) “Structural Models of the Reductase Domain of Nitric Oxide Synthase: Identification of a New Loop That Attenuates Calmodulin-Dependent Activity” Journal of Biological Chemistry, 278(34):31814-24

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