Contact Information:
Email: togihara@iupui.edu
Phone: 317-278-8940
Address: VanNuys Medical Sciences Building, 635 Barnhill Drive, MS 2021, Indianapolis, IN 46202
Education:
Postdoctoral Fellowship: Division of Endocrinology and Metabolism, University of Virginia, Charlottesville, VA, and Department of Endocrinology and Metabolism, School of Medicine, Juntendo University, Tokyo, JAPAN
Ph.D.: Diabetology (2003), Department of Endocrinology and Metabolism, School of Medicine, Juntendo University, Tokyo, JAPAN
M.D.: School of Medicine, Juntendo University, Tokyo, JAPAN (1995)
Research Interests: My research field is developmental biology in pancreas, and focused on the rule of transcription factors, as well as chromatin modification in β cell development.
Publications:
Nakayama S, Arakawa M, Uchida T, Ogihara T, Kanno R, Ikeda F, Azuma K, Hirose T, Kawamori R, Fujitani Y, Watada H. Dose-dependent requirement of patched homologue 1 in mouse pancreatic beta cell mass. Diabetologia. 2008 in press
Ogihara T, Fujitani Y, Uchida T, Kanno R, Choi JB, Hirose T, Kawamori R, Watada H. Combined Expression of Transcription Factors Induces AR42J-B13 Cells to Differentiate into Insulin-Producing Cells. Endocr J. 2008 in press
Kumashiro N, Tamura Y, Uchida T, Ogihara T, Fujitani Y, Hirose T, Mochizuki H, Kawamori R, Watada H. Impact of Oxidative Stress and Peroxisome Proliferator-Activated Receptor gamma Co-activator-1alpha in Hepatic Insulin Resistance. Diabetes. 2008 Aug;57(8):2083-91.
Tamaki M, Tamura Y, Ogihara T, Shimizu T, Uchino H, Hirose T, Kawamori R, Watada H.Lack of evident atherosclerosis despite multiple risk factors in glycogen storage disease type 1a with hyperadiponectinemia. Metabolism. 2007 Oct;56(10):1402-4.
Ikeda F, Azuma K, Ogihara T, Toyofuku Y, Otsuka A, Mita T, Hirose T, Tanaka Y, Kawamori R, Watada H. Angiotensin II type 1 receptor blocker reduces monocyte adhesion to endothelial cells in spontaneously hypertensive rats. Endocr J. 2007 Aug;54(4):605-12.
Mita T, Otsuka A, Azuma K, Uchida T, Ogihara T, Fujitani Y, Hirose T, Mitsumata M, Kawamori R, Watada H. Swings in blood glucose levels accelerate atherogenesis in apolipoprotein E-deficient mice. Biochem Biophys Res Commun. 2007 Jul 6;358(3):679-85.
Mita T, Watada H, Nakayama S, Abe M, Ogihara T, Shimizu T, Uchino H, Hirose T, Kawamori R. Preferable Effect of Pravastatin Compared to Atorvastatin on Beta Cell Function in Japanese Early-state Type 2 Diabetes with Hypercholesterolemia. Endocr J. 2007 Jul;54(3):441-7.
Iwashita N, Uchida T, Choi JB, Azuma K, Ogihara T, Ferrara N, Gerber H, Kawamori R, Inoue M, Watada H. Impaired insulin secretion in vivo but enhanced insulin secretion from isolated islets in pancreatic beta cell-specific vascular endothelial growth factor-A knock-out mice. Diabetologia. 2007 Feb;50(2):380-9.
Uchida T, Iwashita N, Ohara-Imaizumi M, Ogihara T, Nagai S, Choi JB, Tamura Y, Tada N, Kawamori R, Nakayama KI, Nagamatsu S, Watada H. Protein kinase Cdelta plays a non-redundant role in insulin secretion in pancreatic beta cells. J Biol Chem. 2007 Jan 26;282(4):2707-16.
Tamura Y, Ogihara T, Uchida T, Ikeda F, Kumashiro N, Nomiyama T, Sato F, Hirose T, Tanaka Y, Mochizuki H, Kawamori R, Watada H. Amelioration of glucose tolerance by hepatic inhibition of nuclear factor kappaB in db/db mice. Diabetologia. 2007 Jan;50(1):131-41.
Shao J, Iwashita N, Ikeda F, Ogihara T, Uchida T, Shimizu T, Uchino H, Hirose T, Kawamori R, Watada H. Beneficial effects of candesartan, an angiotensin II type 1 receptor blocker, on beta-cell function and morphology in db/db mice. Biochem Biophys Res Commun. 2006 Jun 16;344(4):1224-33.
Mita T, Watada H, Ogihara T, Nomiyama T, Ogawa O, Kinoshita J, Shimizu T, Hirose T, Tanaka Y, Kawamori R. Eicosapentaenoic acid reduces the progression of carotid intima-media thickness in patients with type 2 diabetes. Atherosclerosis. 2007 Mar;191(1):162-7.
Knno R, Ogihara T, Igarashi Y, Tanaka Y, Smith SB, Kojima I, German MS, Kawamori R, Watada H. Activin A-induced expression of PAX4 in AR42J-B13 cells involves the increase in transactivation of E47/E12. Biochim Biophys Acta. 2006 Jan-Feb;1759(1-2):44-50.
Nomiyama T, Igarashi Y, Taka H, Mineki R, Uchida T, Ogihara T, Choi JB, Uchino H, Tanaka Y, Maegawa H, Kashiwagi A, Murayama K, Kawamori R, Watada H. Reduction of insulin-stimulated glucose uptake by peroxynitrite is concurrent with tyrosine nitration of insulin receptor substrate-1. Biochem Biophys Res Commun. 2004 Jul 30;320(3):639-47.
Ogihara T, Watada H, Kanno R, Ikeda F, Nomiyama T, Tanaka Y, Nakao A, German MS, Kojima I, Kawamori R. p38 mitogen-activated protein kinase is involved in activin A- and HGF-mediated expression of pro-endocrine gene neurogenin 3 in AR42J-B13 cells. J Biol Chem 2003 Jun 13;278(24):21693-700
Nomiyama T, Tanaka Y, Piao L, Nagasaka K, Sakai K, Ogihara T, Nakajima K, Watada H, Kawamori R. The polymorphism of manganese superoxide dismutase is associated with diabetic nephropathy in Japanese type 2 diabetic patients. J Hum Genet 2003;48(3):138-41
Nakajima K, Tanaka Y, Nomiyama T, Ogihara T, Ikeda F, Kanno R, Iwashita N, Sakai K, Watada H, Onuma T, Kawamori R. RANTES Promoter Genotype Is Associated With Diabetic Nephropathy in Type 2 Diabetic Subjects. Diabetes Care 2003 Mar;26(3):892-8
Nakajima K, Tanaka Y, Nomiyama T, Ogihara T, Piao L, Sakai K, Onuma T, Kawamori R. Chemokine receptor genotype is associated with diabetic nephropathy in Japanese with type 2 Diabetes. Diabetes. 2002 Jan;51(1):238-42.
Matsunaga H, Tanaka Y, Tanaka M, Gong JS, Zhang J, Nomiyama T, Ogawa O, Ogihara T, Yamada Y, Yagi K, Kawamori R. Antiatherogenic mitochondrial genotype in patients with type 2 diabetes. Diabetes Care. 2001 Mar;24(3):500-3.
Okubo M, Inoue S, Horinishi A, Ogihara T, Kaneko K, Gotoda T, Yamada N, Murase T.Detection of a new compound heterozygote (del G916/G1401A) for lipoprotein lipase deficiency and a comparative haplotype analysis of the mutant lipoprotein lipase gene from Japanese patients. Atherosclerosis. 1999 Jun;144(2):443-7.
