Degree programs in the academic divisions at IUPUI are regionally accredited by the North Central Association of Colleges and Secondary Schools (NCA1), which oversees the processes of academic evaluation and approval for the campus as a separate unit and as a component of the Indiana University and Purdue University multi-campus systems. The NCA has accredited IUPUI degree programs at the associate and baccalaureate levels, in addition to certain master's degree programs. These include the Master of Social Work; the Master of Arts in English and in the teaching of mathematics; Master of Science in agriculture (extension education), chemistry, engineering (interdisciplinary), industrial operations, industrial psychology, elementary education, school administration, special education, and secondary education; and Master of Arts degrees in history and economics. Accreditation for the masters and Ph.D. programs in the basic biomedical sciences is maintained through the IU Graduate School, which has offices on the Bloomington and Indianapolis campuses. These biomedical sciences, based in departments of the School of Medicine and the School of Dentistry, include anatomy, physiology, pathology, medical biophysics, and toxicology. The degree of Master of Business Administration is accredited as a program of the IU School of Business, which conducts academic programs at the Indianapolis and Bloomington campuses.

The IUPUI campus was first accredited by the North Central Association in 1972. The campus was subsequently accredited for ten-year periods in 1982-83 and 1992-93. The latest self-study document can be found in the offices of the Chancellor and the Dean of the Faculties as well as in the Faculty Council Office.

Professional degrees are accredited by various national agencies with relevant review and approval responsibilities in their fields. These bodies include the Liaison Committee on Medical Education (LCME) representing the Association of American Medical Colleges and the Council on Medical Education of the American Medical Association, the American Occupational Therapy Association, the Commission on Accreditation for Physical Therapy Education, the Council on Legal Education of the American Bar Association, the Council on Dental Education of the American Dental Association, the National League for Nursing Board of Review, the Council on Social Work Education, the Engineers' Council for Professional Development, Accreditation Board of Engineering and Technology, the Accrediting Council on Education for Journalism and Mass Communications, and the National Association of Schools of Art.