The goal of our clinical research is to advance our understanding of human diseases and to improve diagnostic and disease-monitoring abilities, resulting in greater treatment effectiveness. Recent advances in high throughput technologies in genomics, proteomics, and metabolomics, as well as advances in informatics to support data analysis are revolutionizing the way clinical research is performed.
Large, well-annotated collections of high quality human specimens are fundamental for clinical researchers to take full advantage of these technologies. To enable this research, the Center has created a Biospecimen Repository containing many types of body fluids and tissues from children and adults from Riley Hospital for Children, the Department of Ophthalmology and the Indiana University General Clinical Research Center.
The main advantages of a central Biospecimen Repository are the optimized quality control of sample processing and banking, the development of new database and management tools, and the ability to link experimental results back to the specimens from which it derived. As part of the Cancer Bioinformatics Grid (caBIG) of the NCI, the Center for Computational Diagnostics at Indiana University was selected as one of the centers to design and adopt caTissue Core, which is a web-based application to manage the processing of specimens. The Biospecimen Repository has been using caTissue Core for high-throughput biospecimen banking in the Departments of Pediatrics and Ophthalmology since the version 1.2 release in June 2007