Bone Biology and Mechanics Lab: BBML

Welcome to the BBML in the Department of Biomedical Engineering at Indiana University-Purdue University at Indianapolis (IUPUI). The BBML is committed to improving our understanding of how the body works through innovative research. As our name implies, the lab focuses on bone mechanics (ability to effectively bear loads) and mechanobiology (how cells respond to mechanical stimuli to maintain and/or increase bone mass). We investigate bone from mechanical engineering and materials science perspectives by tying morphology and composition to mechanical function and fracture resistance at discrete length scales throughout bone's hierarchy.

Bone Hierarchy

Our long-term goal is to use combinatorial treatments for a number of relevant diseases that have musculoskeletal complications which lead to bone fragility and fracture. Our current focus is on mechanical and pharmaceutical manipulations of bone quality and quantity to intervene and increase bone fracture resistance even in the face of inferior tissue quality. A common thread that passes through all of our research is an intense focus on collagen and the role it plays in bone health. Our research is currently funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and the Indiana Clinical and Translational Sciences Institute (CTSI).

Lab Intro

Recent Lab News

NOTE: The lab is looking for a student (MS or PhD) with a strong background in cell culture. A BME student is preferred, but students working toward a degree in other departments are also welcome to apply. This project is ready to start immediately and will require experience working with cells, performing PCR, western blots, and staining assays. Other techincal skills will be learned during the process, including in vitro loading of cells. If interested, please contact Dr. Wallace directly (

The lab wants to welcome our new postdoctoral fellow, Dr. Amy Creecy!

To highlight our new grant, IU has issued a press release. Feel free to contact Dr. Wallace with any question.

The lab was awarded a 5 year grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)! The grant is titled "Targeting collagen as an interventional approach to improve bone material properties." This work is focused on combination treatments which impact bone quantity and quality for a number of relevant diseases which have musculoskeletal complications.

The lab wants to bid farewell to Silvia Canelon and Alexis Pulliam as they move on to the next stages of their acadmemic careers!

Congratulations to Silvia for successfully defending her dissertation, entitled "Characterization of Type I Collagen and Osteoblast Response to Mechanical Loading."

Professor Wallace received the 2018 IUPUI Trustees’ Teaching Award.

The lab wants to welcome Rachel Surridge and Jen Hatch who joined as undergraduate researchers in the Spring of 2018.

Alycia gave a podium presentation at the 2018 Annual Meeting of the Orthopaedic Research Society for her Late Breaking abstract titled "Raloxifene Treatment Enhances Bone Response to Mechanical Tibial Loading in Mice."

Prof. Wallace was invited to join the ORS Membership Committee for a 2 year term (2018-2020).

We want to welcome JD back to the lab. He has chosen to join us for the PhD portion of his Medical Scientist Training Program (MSTP) MD/PhD program. He started back in May 2018!

The lab was awarded a grant from the IUPUI Biomechanics and Biomaterials Research Center The work is titled "Profiling of Raloxifene and Raloxifene Analogs: Effects on Cell Behavior and Bone Material Properties."

Recent Research


A variety of research endeavors are currently underway in the BBML. Our work focuses predominantly on bone, muscle and tendon. Click below to learn more about the general areas of research.

BBML People

BBML People

Click below to learn more about the people in our lab who make all of this exciting work possible.

Recent Publication


Our lab actively publishes in journals spanning the areas of bone and mineral and general biomechanics. To view of list of our publications, click the link below.

Send us a message

Other ways to reach us

  • Associate Professor
    Joseph Wallace

  • BBML: Bone Biology and Mechanics Lab

  • Phone and fax

    JW Office: (317) 274-2448
    Fax: (317) 278-2455
    Lab: (317) 278-1014

  • Facebook

    BBML on Facebook

  • JW Mailing Address

    723 W. Michigan St. SL220
    Indianapolis, IN 46202
    United States

  • Lab Mailing Address

    723 W. Michigan St. SL214
    Indianapolis, IN 46202
    United States