Welcome to the Bone Biology and Mechanics Lab

Welcome to the Bone Biology and Mechanics Lab (BBML) in the Department of Biomedical Engineering at Indiana University-Purdue University at Indianapolis (IUPUI). The BBML is committed to improving our understanding of how the body works through innovative research. Specifically, we take a materials science approach towards tying morphology and composition to mechanical function at discrete length scales throughout the hierarchy of bone (and other musculoskeletal tissues), from the nanoscale structure of collagen and mineral to the whole bone at macroscale.

Bone Hierarchy

The long-term goal of my laboratory is to determine mechanisms by which biological, mechanical and pharmacological factors influence the mechanical integrity of bone at levels throughout the tissue’s hierarchy. Our goal is to translate findings into rational and clinically-relevant diagnostic and treatment options for defects, damage and disease of musculoskeletal tissues. A common thread that passes through all of our research projects is an interest in collagen and the roles collagen plays in bone health. Our research is currently funded by the Office of the Vice Chancellor for Research, the Biomechanics and Biomaterials Research Center, the Indiana Clinical and Translational Sciences Institute (CTSI) and the IUPUI Department of Biomedical Engineering.

Lab Intro