Bone Biology and Mechanics Lab: BBML

Welcome to the BBML in the Department of Biomedical Engineering at Indiana University-Purdue University at Indianapolis (IUPUI). The BBML is committed to improving our understanding of how the body works through innovative research. We are focused on investigating bone from mechanical engineering and materials science perspectives by tying morphology and composition to mechanical function and fracture resistance at discrete length scales throughout bone's hierarchy.

Bone Hierarchy

Our long-term goal is to understand how properties of the bone matrix differ with disease. Using mechanical and pharmaceutical options, we are working on modifying tissue properties to intervene and increase bone fracture resistance even in the face of inferior tissue quality. A common thread that passes through all of our research projects is an intense focus on collagen and the role it plays in bone health. Our research is currently funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the Indiana Clinical and Translational Sciences Institute (CTSI).

Lab Intro

Recent Lab News

The lab was awarded a grant from the IUPUI Biomechanics and Biomaterials Research Center The work is titled "Profiling of Raloxifene and Raloxifene Analogs: Effects on Cell Behavior and Bone Material Properties."

The lab wants to welcome Rachel Surridge and Sabria Abufares who both joined as undergraduate researchers in the Fall of 2017. We would also like to welcome Alexis Pulliman who joined the lab in July 2017 as a member of the IUPUI Post-Baccalaureate Research Education Program (IPREP).

Recent Research


A variety of research endeavors are currently underway in the BBML. Our work focuses predominantly on bone, muscle and tendon. Click below to learn more about the general areas of research.

BBML People

BBML People

Click below to learn more about the people in our lab who make all of this exciting work possible.

Recent Publication


Our lab actively publishes in journals spanning the areas of bone and mineral and general biomechanics. To view of list of our publications, click the link below.

Send us a message

Other ways to reach us

  • Associate Professor
    Joseph Wallace

  • BBML: Bone Biology and Mechanics Lab

  • Phone and fax

    JW Office: (317) 274-2448
    Fax: (317) 278-2455
    Lab: (317) 278-0102

  • Facebook

    BBML on Facebook

  • JW Mailing Address

    723 W. Michigan St. SL220
    Indianapolis, IN 46202
    United States

  • Lab Mailing Address

    723 W. Michigan St. SL214
    Indianapolis, IN 46202
    United States