Bone Biology and Mechanics Lab: BBML

Welcome to the BBML in the Department of Biomedical Engineering at Indiana University-Purdue University at Indianapolis (IUPUI). The BBML is committed to improving our understanding of how the body works through innovative research. We are focused on investigating bone from mechanical engineering and materials science perspectives by tying morphology and composition to mechanical function and fracture resistance at discrete length scales throughout bone's hierarchy.

Bone Hierarchy



Our long-term goal is to understand how properties of the bone matrix differ with disease. Using mechanical and pharmaceutical options, we are working on modifying tissue properties to intervene and increase bone fracture resistance even in the face of inferior tissue quality. A common thread that passes through all of our research projects is an intense focus on collagen and the role it plays in bone health. Our research is currently funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the Indiana Clinical and Translational Sciences Institute (CTSI).

Lab Intro

Recent Lab News

The lab was awarded a 5 year grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)! The grant is titled "Targeting collagen as an interventional approach to improve bone material properties." This work is focused on combination treatments which impact bone quanity and quality for a number of relevant diseases which have musculoskeletal complications.

The lab wants to bid farewell to Silvia Canelon and Alexis Pulliam as they move on to the next stages of their acadmemic careers!

Congratulations to Silvia for successfully defending her dissertation, entitled "Characterization of Type I Collagen and Osteoblast Response to Mechanical Loading."

Professor Wallace received the 2018 IUPUI Trustees’ Teaching Award.

The lab wants to welcome Rachel Surridge and Jen Hatch who joined as undergraduate researchers in the Spring of 2018.

Alycia gave a podium presentation at the 2018 Annual Meeting of the Orthopaedic Research Society for her Late Breaking abstract titled "Raloxifene Treatment Enhances Bone Response to Mechanical Tibial Loading in Mice."

Prof. Wallace was invited to join the ORS Membership Committee for a 2 year term (2018-2020).

We want to welcome JD back to the lab. He has chosen to join us for the PhD portion of his Medical Scientist Training Program (MSTP) MD/PhD program. He started back in May 2018!

The lab was awarded a grant from the IUPUI Biomechanics and Biomaterials Research Center The work is titled "Profiling of Raloxifene and Raloxifene Analogs: Effects on Cell Behavior and Bone Material Properties."

Recent Research

Research

A variety of research endeavors are currently underway in the BBML. Our work focuses predominantly on bone, muscle and tendon. Click below to learn more about the general areas of research.

BBML People

BBML People

Click below to learn more about the people in our lab who make all of this exciting work possible.



Recent Publication

Publications

Our lab actively publishes in journals spanning the areas of bone and mineral and general biomechanics. To view of list of our publications, click the link below.

Send us a message

Other ways to reach us

  • Associate Professor
    Joseph Wallace

    jmwalla@iupui.edu

  • BBML: Bone Biology and Mechanics Lab

    bonebiomechanics@gmail.com

  • Phone and fax

    JW Office: (317) 274-2448
    Fax: (317) 278-2455
    Lab: (317) 278-1014

  • Facebook

    BBML on Facebook

  • JW Mailing Address

    723 W. Michigan St. SL220
    Indianapolis, IN 46202
    United States

  • Lab Mailing Address

    723 W. Michigan St. SL214
    Indianapolis, IN 46202
    United States