Juris Janis Liepnieks, Ph.D., Assistant Scientist.

Tel: (lab) (317) 278-3440 
Fax:        (317) 278-3429 
Email

EDUCATION:

Purdue University B.S. 1969,  Chemistry

Purdue University Ph.D. 1978,  Biochemistry

 

ACADEMIC APPOINTMENTS AND EMPLOYMENT:

1978 - 1982 Postdoctoral Fellow, Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada

1982 - 1984 Research Associate, Laboratory for Experimental Oncology, Indiana University School of Medicine, Indianapolis, IN

1984 - 1984 Research Associate, Krannert Institute of Cardiology, Indianapolis, IN

1984 - 1987 Research Chemist, Endocrinology Section, Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis, IN

1987 - 1989 Research Chemist, Rheumatology Section, Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis, IN

1989 - 1989 Visiting Professor, Indiana University School of Medicine, Indianapolis, IN

1989 - 1997 Assistant Scientist, Department of Medicine Indiana University School of Medicine, Indianapolis, IN

1989 - 1998 Research Chemist, Rheumatology Section, Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis, IN

1997 - Assistant Scientist, Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 

PROFESSIONAL ORGANIZATIONS:

American Chemical Society

American Association for the Advancement of Science 

PUBLICATIONS:

1. Liepnieks, J.J. and Light, A.: Preparation of beta-trypsin by affinity chromatography of enterokinase-activated bovine trypsinogen. Anal. Biochem. 60:395-404, 1974.

2. Light, A. and Liepnieks, J.J.: Bovine beta-trypsin. Methods in Enzymol. 34:448-451, 1974.

3. Liepnieks, J.J.: Purification and characterization of bovine enterokinase isolated from duodenal mucosa. Doctor of Philosophy Thesis. 1978.

4. Light, A., Pande, C.S., and Liepnieks, J.J.: Solid-phase active site inhibitors of proteinases. Int. J. Peptide Protein Res. 13:88-94, 1979.

5. Liepnieks, J.J. and Light, A.: The preparation and properties of bovine entero-kinase. J. Biol. Chem. 254:1677-1683, 1979.

6. Light, A., Savithri, H.S., and Liepnieks, J.J.: Specificity of bovine enterokinase toward protein substrates. Anal. Biochem. 106:199-206, 1980.

7. Liepnieks, J.J. and Epand, R.M.: Differential acid stabilities of citraconylated amino groups of glucagon: Preparation of N-alpha-citraconyl glucagon and evaluation of its biological properties. Biochem. Biophys. Acta 707:171-177, 1982.

8. Epand, R.M. and Liepnieks, J.J.: Conformational and biological properties of di[delta-(5-nitro-2-pyrimidyl) ornithine17,18]-glucagon: Role of the arginine residues. J. Biol. Chem. 258:203-207, 1983.

9. Liepnieks, J.J., Stoskopf, P., Carrey, E.A., Prosser, C., and Epand, R.M.: The biological activity of glucagon-phospholipid complexes. Can. J. Biochem. Cell Biol. 61:688-691, 1983.

10. Liepnieks, J.J. and Epand, R.M.: Effect of specific trinitrophenylation of the lysine epsilon amino group of glucagon on receptor binding and adenylate cyclase activation. Arch. Biochem. Biophys. 225:102-109, 1983.

11. Lui, M.S., Faderan, M.A., Liepnieks, J.J., Natsumeda, Y., Olah, E., Jayaram, H.N., and Weber, G.: Modulation of IMP dehydrogenase activity and guanylate metabolism by tiazofurin (2-beta-D-Ribofuranosylthiazole-4-carboxamide). J. Biol. Chem. 259:5078-5082, 1984.

12. Weber, G., Natsumeda, Y., Lui, M.S., Faderan, M.A., Liepnieks, J.J., and Elliott, W.L.: Control of enzymic programs and nucleotide pattern in cancer cells by acivicin and tiazofurin. Advan. Enzyme Regul. 22:69-93, 1984.

13. Liepnieks, J.J., Faderan, M.A., Lui, M.S., and Weber, G.: Tiazofurin-induced selective depression of NAD content in hepatoma 3924A. Biochem. Biophys. Res. Commun. 122:345-349, 1984.

14. Wegener, A.D., Simmerman, H.K.B., Liepnieks, J.J., and Jones, L.R.: Proteolytic cleavage of phospholamban purified from canine cardiac sarcoplasmic reticulum vesicles: Generation of a low resolution model of phospholamban structure. J. Biol. Chem. 261:5154-5159, 1986.

15. Duckworth, W.C., Hamel, F.G., Liepnieks, J.J., Peavy, D.E., Ryan, M.P., Hermodson, M.A., and Frank, B.H.: Identification of A chain cleavage sites in intact insulin produced by insulin protease and isolated hepatocytes. Biochem. Biophys. Res. Commun. 147:615-621, 1987.

16. Duckworth, W.C., Hamel, F.G., Peavy, D.E., Liepnieks, J.J., Ryan, M.P., Hermodson, M.A., and Frank, B.H.: Degradation products of insulin generated by hepatocytes and by insulin protease. J. Biol. Chem. 263:1826-1833, 1988.

17. Duckworth, W.C., Solomon, S.S., Liepnieks, J.J., Hamel, F.G., Hand, S., and Peavy, D.E.: Insulin-like effects of vanadate in isolated rat adipocytes. Endocrinology, 122:2285-2289, 1988.

18. Duckworth, W.S., Peavy, D.E., Hamel, F.G., Liepnieks, J.J., Heiney, R., and Frank, B.H.: Conversion of biosynthetic human proinsulin to partially cleaved intermediates by collagenase proteinases adsorbed to isolated rat adipocytes. Biochem. J. 255:277-284, 1988.

19. Duckworth, W.C., Hamel, F.G., Liepnieks, J.J., Frank, B.H., Yagil, C. and Rabkin, R.: High performance liquid chromatographic analysis of insulin degradation products from a cultured kidney cell line. Endocrinology 123:2701-2708, 1988. 
20. Nichols, W.C., Dwulet, F.E., Liepnieks, J., and Benson, M.D.: Variant apolipoprotein AI as a major constituent of human hereditary amyloid. Biochem. Biophys. Res. Commun. 156:762-768, 1988.

21. Duckworth, W.C., Garcia, J.V., Liepnieks, J.J., Hamel, F.G., Hermodson, M.A., Frank, B.H., and Rosner, M.R.: Drosophila insulin degrading enzyme and rat skeletal muscle insulin protease cleave insulin at similar sites. Biochemistry 28:2471-2477, 1989.

22. Duckworth, W.C., Hamel, F.G., Liepnieks, J.J.,  Peavy, D.E., Frank, B.H., and Rabkin, R.: Insulin degradation products from perfused rat kidney. Am. J. Physiol. 256 (Endocrinol. Metab. 19):E208-E214, 1989.

23. Nichols, W.C., Liepnieks, J.J., McKusick, V.A. and Benson, M.D.: Direct sequencing of the gene for Maryland/German familial amyloidotic polyneuropathy type II and genotyping by allele-specific enzymatic amplification. Genomics 5:535-540, 1989.

24. Carothers, M.A., Johnson, G.C., DiBartola, S.P., Liepnieks, J.J., and Benson, M.D.: Extramedullary plasmacytoma and immunoglobulin-associated amyloidosis in a cat. J. Am. Vet. Med. Assoc. 195:1593-1597, 1989.

25. Liepnieks, J.J., Dwulet, F.E., and Benson, M.D.: Amino acid sequence of a kappa I primary (AL) amyloid protein (AND). Mol. Immunol. 27:481-485, 1990.

26. Moses, A.C., Rosen, H.N., Moller, D.E., Tsuzaki, S., Haddow, J.E., Lawlor, J., Liepnieks, J.J., Nichols, W.C. and Benson, M.D.: A point mutation in transthyretin increases affinity for thyroxine and produces euthyroid hyperthyroxinemia. J. Clin. Invest. 86:2025-2033, 1990.

27. Nichols, W.C., Liepnieks, J.J., Snyder, E.L. and Benson, M.D.: Senile cardiac amyloidosis associated with homozygosity for a transthyretin variant (Ile-122). J. Lab. Clin. Med. 117: 175-180, 1991.

28. Quinn, L., Shafer, E., Liepnieks, J.J. and Benson, M.D.: Reactive (AA) amyloidosis in a 14 year old with no predisposing disease. In Amyloid and Amyloidosis 1990 Ed. by Natvig, J.B., Forre, O., Husby, G., Husebekk, A., Skogen, B., Sletten, K. and Westermark, P. 91-94. Kluwer Academic Publishers, Dordrecht, The Netherlands 1991.

29. Kluve-Beckerman, B., Liepnieks, J.J. and Benson, M.D.: Differential regulation of human serum amyloid A isoforms. In Amyloid and Amyloidosis 1990 Ed. by Natvig, J.B., Forre, O., Husby, G., Husebekk, A., Skogen, B., Sletten, K. and Westermark, P. 125-128. Kluwer Academic Publishers, Dordrecht, The Netherlands 1991.

30. Liepnieks, J.J., Benson, M.D. and Dwulet, F.E.: Comparison of the amino acid sequences of ten kappa I amyloid proteins for amyloidogenic sequences. In Amyloid and Amyloidosis 1990 Ed. by Natvig, J.B., Forre, O., Husby, G., Husebekk, A., Skogen, B., Sletten, K. and Westermark, P. 153-156. Kluwer Academic Publishers, Dordrecht, The Netherlands 1991.

31. Liepnieks, J.J., Benson, M.D. and Di Bartola, S.P.: Systemic AL amyloidosis in a cat. In Amyloid and Amyloidosis 1990 Ed. by Natvig, J.B., Forre, O., Husby, G., Husebekk, A., Skogen, B., Sletten, K. and Westermark, P. 189-192. Kluwer Academic Publishers, Dordrecht, The Netherlands 1991.

32. Liepnieks, J.J., Leagre, C., Kluve-Beckerman, B. and Benson, M.D.: Predominance of one SAA isotype (SAAI) in human reactive amyloid. In Amyloid and Amyloidosis 1990 Ed. by Natvig, J.B., Forre, O., Husby, G., Husebekk, A., Skogen, B., Sletten, K. and Westermark, P. 511-514. Kluwer Academic Publishers, Dordrecht, The Netherlands 1991.

33. Hamilton, J.A., Steinrauf, L.K., Liepnieks, J.J., Benson, M.D. Holmgren, G., Sandgren, O. and Steen, L.: X-ray crystal structure of the met-30 variant of human prealbumin (transthyretin). In Amyloid and Amyloidosis 1990 Ed. by Natvig, J.B., Forre, O., Husby, G., Husebekk, A., Skogen, B., Sletten, K. and Westermark, P. 579-582. Kluwer Academic Publishers, Dordrecht, The Netherlands 1991.

34. Liepnieks, J.J., Dwulet, F.E., Benson, M.D., Kluve-Beckerman, B. and Kushner, I.: The primary structure of serum amyloid A protein in the rabbit: Comparison to SAA proteins in other species. J. Lab. Clin. Med. 118:570-575, 1991.

35. Steinrauf, L.K., Cao, Y., Hamilton, J., Murrell, J., Liepnieks, J.J.. and Benson, M.D.: Preparation and crystallization of human transthyretin (prealbumin) variants. Biochem. Biophys. Res. Commun. 179:804-809, 1991.

36. Hamilton, J.A., Steinrauf, L.K., Liepnieks, J.J., Benson, M.D., Holmgren, G., Sandgren, O. and Steen, L.: Alteration in molecular structure which results in disease: The Met-30 variant of human plasma transthyretin. Biochim. Biophys. Acta, 1139:9-16, 1992.

37. Murrell, J.R., Schoner, R.G., Liepnieks, J.J., Rosen, H.N., Moses, A.C. and Benson, M.D.: Production and functional analysis of normal and variant recombinant human transthyretin proteins. J. Biol. Chem. 267:16595-16600, 1992.

38. Rosen, H.N., Moses, A.C., Murrell, J.R., Liepnieks, J.J., Holmgren, G., Sandgren, O., Steen, L. and Benson, M.D.: Thyroxine interactions with transthyretin: A comparison of 10 different naturally-occurring transthyretin variants. J. Clin. Endo. Metab. 77:370-374, 1993.

39. Benson II, M.D., Julien, J., Liepnieks, J., Zeldenrust, S., and Benson, M.D.: A transthyretin variant (Alanine 49) associated with familial amyloidotic polyneuropathy in a French family. J. Med. Genet., 30:117-119, 1993.

40. Fife, R.S., Kluve-Beckerman, B., Houser, D.S., Proctor, C., Liepnieks, J.J.., Masuda, I., McCarty, D.J., and Ryan, L.M.: Evidence that a 550,000-dalton cartilage matrix glycoprotein is a chondrocyte membrane-associated protein closely related to ceruloplasmin. J. Biol. Chem. 268:4407-4411, 1993.

41. Kluve-Beckerman, B., Song, M., Benson, M.D. and Liepnieks, J.J.: Recombinant murine serum amyloid A from baculovirus-infected insect cells: Purification and characterization. Biochim. Biophys. Acta 1182:303-310, 1993.

42. Benson, M.D., Liepnieks, J., Uemichi, T., Wheeler, G. and Correa, R.: Hereditary renal amyloidosis associated with a mutant fibrinogen "-chain. Nature Genet. 3:252-255, 1993.

43. Hamilton, J.A., Steinrauf, L.K., Braden, B.C., Liepnieks, J.J., Benson, M.D., Holmgren, G., Sandgren, O. and Steen, L.: The X-ray crystal structure refinements of normal human transthyretin and the amyloidogenic Val-306Met variant to 1.7Å resolution. J. Biol. Chem. 268:2416-2424, 1993.

44. Liepnieks, J.J.., Ghetti, B., Farlow, M.J., Roses, A.D., and Benson, M.D.: Characterization of amyloid fibril ß-peptide in familial alzheimer's disease with APP717 mutations. Biochem. Biophys. Res. Commun. 197:386-392, 1993.

45. Rosen, H.N., Murrell, J.R., Liepnieks, J.J., Benson, M.D., Cody, V., and Moses, A.C.: Threonine-for-alanine substitution at position 109 of transthyretin differentially alters TTR's affinity for iodothyronines. Endocrinology 134:27-34, 1994.

46. Yamada, T., Kluve-Beckerman, B., Liepnieks, J.J., and Benson, M.D.: Fibril formation from recombinant human serum amyloid A. Biochim. Biophys. Acta 1226:323-329, 1994.

47. Uemichi, T., Liepnieks, J.J., and Benson, M.D.: Hereditary renal amyloidosis with a novel variant fibrinogen. J. Clin. Invest. 93:731-736, 1994.

48. Yamada, T., Kluve-Beckerman, B., Kuster, W.M., Liepnieks, J.J., and Benson, M.D.: Measurement of serum amyloid A4 (SAA4), its constitutive presence in serum. Amyloid: Int. J. Exp. Clin. Invest. 1:114-118, 1994.

49. Uemichi, T., Liepnieks, J.J., Altland, K., and Benson, M.D.: Identification of a novel non-amyloidogenic transthyretin polymorphism (His-74) in the German population. Amyloid: Int. J. Exp. Clin. Invest. 1:149-153, 1994.

50. Berni, R., Malpeli, G., Folli, C., Murrell, J.R., Liepnieks, J.J., and Benson, M.D.: The Ile-846Ser amino acid substitution in transthyretin interferes with the interaction with plasma retinol-binding protein. J. Biol. Chem. 269:23395-23398, 1994.

51. Kluve-Beckerman, B., Song, M., Benson, M.D. and  Liepnieks, J.J.: Baculovirus-infected insect cells as a source of isotypically pure, radiolabeled murine SAA2. In Amyloid and Amyloidosis 1993, Ed. by Kisilevsky, R., Benson, M.D., Frangione, B., Gauldie, J., Muckle, T.J. and Young, I.D., pp. 38-40. Parthenon Publishing Group Inc., New York and London, 1994.

52. Yamada, T., Kluve-Beckerman, B., Benson, M.D. and  Liepnieks, J.J.: Efficient production of recombinant human serum amyloid A proteins. In Amyloid and Amyloidosis 1993, Ed. by Kisilevsky, R., Benson, M.D., Frangione, B., Gauldie, J., Muckle, T.J. and Young, I.D., pp. 128-130. Parthenon Publishing Group Inc., New York and London, 1994.

53. Benson, M.D., Hamilton, J., Braden, B., Liepnieks, J. and Murrell, J.: X-ray crystallographic analysis of an AL kappa light chain to 2 Å resolution. In Amyloid and Amyloidosis 1993, Ed. by Kisilevsky, R., Benson, M.D., Frangione, B., Gauldie, J., Muckle, T.J. and Young, I.D., pp. 218-220. Parthenon Publishing Group Inc., New York and London, 1994.

54. Liepnieks, J.J., Weisberger, E. and Benson, M.D.: Characterization of AL lambda III protein WHIT from a nasopharyngeal plasmacytoma. In Amyloid and Amyloidosis 1993, Ed. by Kisilevsky, R., Benson, M.D., Frangione, B., Gauldie, J., Muckle, T.J. and Young, I.D., pp. 262-264. Parthenon Publishing Group Inc., New York and London, 1994.

55. Liepnieks, J.J., Prueter, J.C. and Benson, M.D.: AL amyloidosis in a dog. In Amyloid and Amyloidosis 1993, Ed. by Kisilevsky, R., Benson, M.D., Frangione, B., Gauldie, J., Muckle, T.J. and Young, I.D., pp. 305-307. Parthenon Publishing Group Inc., New York and London, 1994.

56. Benson, M.D., Liepnieks, J.J.., Ghetti, B. and Farlow, M.: Primary structure of $-peptide in Alzheimer's disease associated with APP mutation Val717Phe. In Amyloid and Amyloidosis 1993, Ed. by Kisilevsky, R., Benson, M.D., Frangione, B., Gauldie, J., Muckle, T.J. and Young, I.D., pp. 353-355. Parthenon Publishing Group Inc., New York and London, 1994.

57. Uemichi, T., Liepnieks, J.J. and Benson, M.D.: Fibrinogen A" chain variants and hereditary amyloidosis. InAmyloid and Amyloidosis 1993, Ed. by Kisilevsky, R., Benson, M.D., Frangione, B., Gauldie, J., Muckle, T.J. and Young, I.D., pp. 554-556. Parthenon Publishing Group Inc., New York and London, 1994.

58. Liepnieks, J.J., Kluve-Beckerman, B., and Benson, M.D.: Characterization of amyloid A protein in human secondary amyloidosis: The predominant deposition of serum amyloid A1. Biochem. Biophys. Acta. 1270:81-86, 1995.

59. Yamada, T., Liepnieks, J.J., Kluve-Beckerman, B., and Benson, M.D.: Cathepsin B generates the most common form of amyloid A (76 residues) as a degradation product from serum amyloid A. Scand. J. Immunol. 41:94-97, 1995.

60. Eilam, O., Liepnieks, J., Weisberger, E., and Benson, M.D.: Plasmacytoma of the nasal cavity with lambda III amyloid deposition. Amyloid: Int. J. Exp. Clin. Invest. 2:31-35, 1995.

61. Yamada, T., Kluve-Beckerman, B., Liepnieks, J.J., and Benson, M.D.: In Vitro degradation of serum amyloid A by cathepsin D and other acid proteases: Possible protection against amyloid fibril formation. Scand. J. Immunol. 41:570-574, 1995.

62. Schormann, N., Murrell, J.R., Liepnieks, J.J.., and Benson, M.D.: Tertiary struc-ture of an amyloid immunoglobulin light chain protein: A proposed model for amyloid fibril formation. Proc. Natl. Acad. Sci. USA 92:9490-9494, 1995.

63. Liepnieks, J.J., DiBartola, S.P., and Benson, M.D.: Systemic immunoglobulin (AL) amyloidosis in a cat: Complete primary structure of a feline lambda light chain. Amyloid: Int. J. Exp. Clin. Invest. 3:177-182, 1996.

64. Yamada, T., Liepnieks, J., Benson, M.D., and Kluve-Beckerman, B.: Accelerated amyloid deposition in mice treated with the aspartic protease inhibitor, pepstatin. J. Immunol. 157:901-907, 1996.

65. Uemichi, T., Liepnieks, J.J., Yamada, T., Gertz, M.A., Bang, N., and Benson, M.D.: A frame shift mutation in the fibrinogen A" chain gene in a kindred with renal amyloidosis. Blood 87:4197-4203, 1996.

66. Uemichi, T., Liepnieks, J.J., F. Alexander, and Benson, M.D.: The molecular basis of renal amyloidosis in Irish-American and Polish-Canadian kindreds. Q. J. Med. 89:745-750, 1996.

67. Uemichi, T., Liepnieks, J.J., Benson, M.D.: A trinucleotide deletion in the transthyretin gene ()V122) in a kindred with familial amyloidotic polyneuropathy. Neurology 48:1667-1670, 1997.

68. Kluve-Beckerman, B., Yamada, T., Hardwick, J., Liepnieks, J.J., and Benson, M.D.: Differential plasma clearance of murine acute-phase serum amyloid A proteins SAA1 and SAA2. Biochem. J. 322:663-669, 1997.

69. Hamidi Asl, L., Liepnieks, J.J.., Uemichi, T., Rebebou, J.M., Justrabo, E., Droz, D., Mousson, C., Chalopin, J.M., Benson, M.D., Delpech, M., and Grateau, G.: Renal amyloidosis with a frame shift mutation in fibrinogen A"-chain producing a novel amyloid protein. Blood 90:4799-4805, 1997.

70. Hamidi Asl, K.,  Liepnieks, J.J., Bihrle, R., and Benson, M.D.: Local synthesis of amyloid fibril precursor in AL amyloidosis of the urinary tract. Amyloid: Int. J. Exp. Clin. Invest. 5:49-54, 1998.

71. Kluve-Beckerman, B., Hardwick, J., and Liepnieks, J.J.: Direct evidence that serum amyloid A (SAA):HDL interaction requires the amino-terminal portion of SAA. Submitted.

72. Uemichi, T., Liepnieks, J.J., Gertz, M.A., Benson, M.D.: Fibrinogen A" chain Leu554: An African-American kindred with late onset renal amyloidosis. Amyloid: Int. J. Exp. Clin. Invest. 5:188-192, 1998.

73. Hamidi Asl, L., Liepnieks, J.J., Hamidi Asl, K., Uemichi, T., Moulin, G., Desjoyaux, E., Loire, R., Delpech, M., Grateau, G., and Benson, M.D.: Hereditary amyloid cardiomyopathy caused by a variant apolipoprotein AI gene. Am. J. Pathol. 154:221-227, 1999.

74. Kluve-Beckerman, B., Liepnieks, J.J., Wang, L. and Benson, M.D.: A cell culture system for the study of amyloid pathogenesis: Amyloid formation by murine peritoneal cells in the presence of recombinant serum amyloid A. Am J. Pathol. 155:123-133, 1999.

75. Hamidi Asl, K., Liepnieks, J.J., Nakamura, M., and Benson, M.D.: Organ specific (localized) synthesis of Ig light chain amyloid. J. Immunol. 162:5556-5560, 1999.

76. Wally, J., Kica, G., Zhang, Y., Ericsson, T., Connors, L., Benson, M.D., Liepnieks, J.J., Murray, J., Skinner, M., Comenzo, R.L.: Identification of a novel substitution in the constant region of a gene coding for an amyloidogenic kappa 1 light chain. Biochem. Biophys. Acta 1454:49-56, 1999.

77. Hamidi Asl, K.,  Liepnieks, J.J., Nakamura, M., Parker, F., and Benson, M. D.: A novel apolipoprotein A-1 variant, Arg173Pro, associated with cardiac and cutaneous amyloidosis. Biochem. Biophys. Res. Commun. 257:584-588, 1999.

79. Wang, L., Kluve-Beckerman, B., Liepnieks, J.J., and Benson, M. D.: Expression of apoSAACE/J and amyloidogenesis in congenic mice of CE/J and C57BL strains. Submitted.

80. Orpiszewski, J., Schormann, N., Kluve-Beckerman, B., Liepnieks, J.J., and Benson, M. D.: Protein aging hypothesis of Alzheimer disease. Submitted. 

 ABSTRACTS:

1. Liepnieks, J. and Light, A.: Preparation of beta-trypsin from the activation of bovine trypsinogen with enterokinase. Federation Proc. 32:503, 1973.

2. Liepnieks, J.J. and Light, A.: Purification and properties of bovine enterokinase. Federation Proc. 35:1460, 1976.

3. Liepnieks, J.J. and Light, A.: Bovine enterokinase isolated from duodenal mucosa. 1978 Joint Central Great Lakes ACS Meeting.

4. Light, A., Savithri, H.S., and Liepnieks, J.J.: Limited hydrolysis of proteins with bovine enterokinase. XIth International Congress of Biochemistry Abstracts, p. 231, 1979.

5. Jean-Baptiste, E., Liepnieks, J., Epand, R.M., and Rizack, M.A.: Lipolytic and adenylate cyclase activities of glucagon analogs in adipose-tissue. Federation Proc. 39:730, 1980.

6. Lui, M.S., Faderan, M.A., Liepnieks, J.J., Natsumeda, Y., Jayaram, H.N., Ahluwalia, G.S., and Weber, G.: Biochemical and oncolytic action of tiazofurin (TR) in hepatoma. Proc. Am. Assoc. Cancer Res. 25:345, 1984.

7. Wegener, A., Liepnieks, J., Simmerman, H., and Jones, L.: Proteolytic analysis of phospholamban (PLB) structure - generation of a low resolution model. Biophys. J. 47:59a, 1985.

8. Ryan, M.P., Liepnieks, J., Yoon, E., and Duckworth, W.C.: Mechanisms of insulin degradation: Separation of distinct calcium-dependent and non-calcium-dependent insulin-degrading proteases. 67th Annual Meeting of the Endocrine Society, Program and Abstracts, p. 68, 1985.

9. Duckworth, W.C., Ryan, M.P., Liepnieks, J., and Frank, B.H.: Distinct insulin and proinsulin degradation activities from rat skeletal muscle. Proceedings of the 12th Congress of the International Diabetes Federation in Diabetes Research and Clinical Practice, p. 5144 (Suppl. 1), 1985.

10. Duckworth, W.C., Peavy, D.E., Ryan, M.P., Hamel, F.G., and Liepnieks, J.J.: Insulin degradation products from hepatocytes: Similarity with insulin protease-generated fragments. Clin. Res. 34:682A, 1986.

11. Ryan, M.P., Hammond, J.C., Liepnieks, J., and Duckworth, W.C.: Extra-pancreatic proinsulin metabolism: Isolation of the major proinsulin-degrading protease of rat skeletal muscle. Clin. Res. 34:553A, 1986.

12. Rabkin, R., Hamel, F., Liepnieks, J., Peavy, D., Frank, B. and Duckworth, W.C.,: Evidence that an extralysosomal enzyme participates in renal insulin degradation. Clin. Res. 36:525A, 1988.

13. Hamel, F., Rosner, M., Liepnieks, J., and Duckworth, W.C.: Degradation products of Drosophila insulin degrading enzyme and rat insulin protease. Diabetes 37, Suppl. 1:95A, 1988.

14. Nichols, W.C., Liepnieks, J.J., McKusick, V.A. and Benson, M.D.: A prealbumin (transthyretin) mutation associated with familial amyloidotic polyneuropathy type II (Maryland/ German). Clin. Res. 37:542A, 1989.

15. Nichols, W.C., Liepnieks, J.J., McKusick, V.A. and Benson, M.D.: A prealbumin (transthyretin) mutation associated with Maryland/German hereditary amyloidosis. Arthritis and Rheum. 32:S145, 1989.

16. Snyder, E.L., Nichols, W.C., Liepnieks, J.J. and Benson, M.D.: Direct evidence for the hereditary nature of senile cardiac (systemic) amyloidosis. Am. J. Hum. Genet. 45:A220, 1989.

17. Nichols, W.C., Liepnieks, J.J., McKusick, V.A. and Benson, M.D.: A histidine for leucine substitution at position 58 of prealbumin (transthyretin) is associated with FAP II (Maryland/German): Direct DNA sequencing of the gene and geno-typing by allele-specific enzymatic amplification. 1st Int'l. Symposium on Familial Amyloidotic Polyneuropathy, 1989.

18. Nichols, W.C., Snyder, E.L., Liepnieks, J.J. and Benson, M.D.: Senile Cardiac Amyloidosis is a hereditary disease. 1st Int'l. Symposium on Familial Amyloidotic Polyneuropathy, 1989.

19. Moses, A.C., Rosen, H.N., Benson, M.D., Nichols, W.C., Liepnieks, J.J., Tsuzaki, S. and Moller, D.E.: The molecular basis for dysprealbuminemic euthyroid hyperthyroixinemia. Clin. Res. 38:476A, 1990.

20. Rosen, H.N., Benson, M.D., Liepnieks, J.J., Holmgren, G., Sandgren, O., Steen, L., and Moses, A.C.: Thyroxine interactions with transthyretin: a comparison of 10 different naturally occurring variants. Tenth International Thyroid Congress, 1990.

21. Fife, R.S., Houser, D., Proctor, C., Kluve-Beckerman, B., Liepnieks, J., Masuda, I., McCarty, D.J. and Ryan, L.M.: Cartilage Matrix glycoprotein (GMPG) is a chondrocyte membrane - associated protein with sequence homology to ceruloplasmin (CP). Clin. Res. 40:360A, 1992.

22. Aldo-Benson, M., Pratt, L., Liepnieks, J., and Benson, M.D.: Molecular characterization of a 60 kd IL-4 binding protein. Clin. Res 40:184A, 1992.