NIH
Guidelines for Transgenic Animals
The IUPUI IBC to the
Office of Biotechnology Activities, NIH, submitted the following questions:
IBC
Question 1
For transgenic animals, particularly mice and transgenic meaning "expressing
a gene" and not a knock-out; if the investigator has the animals made for
them or purchases these animals, some investigators have felt this means the
studies are exempt. We have interpreted the guidelines such that they are
not exempt and fall, at a minimum, at the BL-1 level. Can you clarify?
NIH Response
In response to your first question, the language in the NIH Guidelines specifically
mentions only purchase and transfer of transgenics being exempt (assuming
BL-1). The use of the animal is not exempt from the NIH Guidelines.
The use is an area where the IBC at a minimum has to be consulted and the
experiments with the animal have to be done at BL-1 or above, as appropriate.
IBC Question 2
We have been treating knock-out mice as BL-1 since the germ line is altered
and the way they are made requires recombinant techniques. However, once they
are made a number of investigators are arguing that they should be exempt.
I fall into the group that feels they should be BL-1 or higher, but would
like your input.
NIH Response
In response to question number 2, I agree with your assessment that the NIH
Guidelines do not distinguish between the generation of the knock-out and
its use. Therefore under Section III-D-4 of the NIH Guidelines, it seems that
BL-1 (or higher, if appropriate) is required. In general, the NIH Guidelines
serve to provide guidance on minimal levels of containment. It
is within the purview of the IBC to increase the containment level for any
type of research that is defined in the NIH Guidelines.
For
additional online information relating to IBC policies go to: http://www.iupui.edu/~resgrad/spon/rescompcontent2.htm.
Workshops
for Future Faculty, Grant Searching, and Proposal Development
Information online is available at:
http://www.opd.iupui.edu/common/events.asp?unit=SCA.
To register for any of these sessions: email opd@iupui.edu.
For additional information, contact Ann Kratz, email akratz@iupui.edu
or call 278-0249.
PREPARING FUTURE FACULTY PROGRAM: Orientation
Session
Thursday 9/6/2001
4:00 - 5:00 p.m.
University Library Room 1125M
The Preparing Future Faculty program will assist you in exploring the role
of a faculty member on a university or college campus. Ways to make this happen
will be the focus of the Orientation Session designed to acquaint prospective
participants with the program and with available resources. Potential PFF
participants will include: advanced graduate students, doctoral students,
postdocs, and academic professionals.
Grant Search Workshop for Faculty
Monday 9/10/2001
9:00 - 10:30 a.m.
University Library Room 1130
This session will showcase and demonstrate several knowledge management service
systems available by University subscriptions that contain thousands of funding
opportunities. Particular emphasis will be placed on using the Faculty Profile
and Weekly Funding Alert systems. The session is designed to introduce you
to the Community of Science/Scholars and SPIN tools and learn how to make
them work for you.
Grant Search Workshop for Graduate Students
Monday 9/10/2001
11:00 - 12:30 p.m.
University Library Room 1130
This session will showcase and demonstrate several knowledge management service
systems available by University subscriptions that contain thousands of funding
opportunities. The session is designed to introduce you to the Community of
Science/Scholars and SPIN tools and learn how to make them work for you.
Proposal Development Workshop for Faculty
Monday 9/17/2001
9:00 - 10:30 a.m.
University Library Room 1125M
The session will focus on the essentials of building a successful grant proposal.
A variety of topics from basic budgets to writing style, interpreting agency
guidelines to securing institutional review board approval, will be covered.
Proposal Development Workshop for Graduate Students
Monday 9/17/2001
11:00 - 12:30 p.m.
University Library Room 1125M
The session will focus on the essentials of building a successful grant proposal.
A variety of topics from basic budgets to writing style, interpreting agency
guidelines to securing institutional review board approval, will be covered.
Grant Search Workshop for Faculty
Thursday 10/11/2001
2:00 - 3:30 p.m. University Library Room 1130
This session will showcase and demonstrate several knowledge management service
systems available by University subscriptions that contain thousands of funding
opportunities. Particular emphasis will be placed on using the Faculty Profile
and Weekly Funding Alert systems. The session is designed to introduce you
to the Community of Science/Scholars and SPIN tools and learn how to make
them work for you.
Grant Search Workshop for Graduate Students
Thursday 10/11/2001
4:00 - 5:30 p.m.
University Library Room 1130
This session will showcase and demonstrate several knowledge management service
systems available by University subscriptions that contain thousands of funding
opportunities. The session is designed to introduce you to the Community of
Science/Scholars and SPIN tools and learn how to make them work for you.
Proposal Development Workshop for Faculty
Thursday 10/25/2001
2:00 - 3:30 p.m.
University Library Room 1125M
The session will focus on the essentials of building a successful grant proposal.
A variety of topics from basic budgets to writing style, interpreting agency
guidelines to securing institutional review board approval, will be covered.
Proposal Development Workshop for Graduate Students
Thursday 10/25/2001
4:00 - 5:30 p.m.
University Library Room 1125M
The session will focus on the essentials of building a successful grant proposal.
A variety of topics from basic budgets to writing style, interpreting agency
guidelines to securing institutional review board approval, will be covered.
Grant Search Workshop for Faculty
Tuesday 11/6/2001
5:30 - 7:00 p.m.
University Library Room 1130
This session will showcase and demonstrate several knowledge management service
systems available by University subscriptions that contain thousands of funding
opportunities. Particular emphasis will be placed on using the Faculty Profile
and Weekly Funding Alert systems. The session is designed to introduce you
to the Community of Science/Scholars and SPIN tools and learn how to make
them work for you.
Grant Search Workshop for Graduate Students
Tuesday 11/6/2001
7:30 - 9:00 p.m.
University Library Room 1130
This session will showcase and demonstrate several knowledge management service
systems available by University subscriptions that contain thousands of funding
opportunities. The session is designed to introduce you to the Community of
Science/Scholars and SPIN tools and learn how to make them work for you.
PREPARING FUTURE FACULTY PROGRAM: Capstone Experience
Monday 11/26/2001
4:00 - 5:00 p.m.
University Library Room 1125M
PFF Participants will be assisted in preparing a dossier to document the events
and activities they participated in during the semester in order to qualify
for a Letter of Participation.
Proposal Development Workshop for Faculty
Tuesday 11/27/2001
5:30 - 7:00 p.m.
University Library Room 1125M
The session will focus on the essentials of building a successful grant proposal.
A variety of topics from basic budgets to writing style, interpreting agency
guidelines to securing institutional review board approval, will be covered.
Proposal Development Workshop for Graduate Students
Tuesday 11/27/2001
7:30 - 9:00 p.m.
University Library Room 1125M
The session will focus on the essentials of building a successful grant proposal.
A variety of topics from basic budgets to writing style, interpreting agency
guidelines to securing institutional review board approval, will be covered.
|
|
Research and Sponsored
Programs
UN 618
General - 274-8285
Research Compliance - 274-8289
Sponsored Program Development - 278-0249
|
|
|
|
Please send comments,
requests to subscribe or unsubscribe, to RSPCOMMU@iupui.edu.
|
